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Month July 2017

Decreased plasma β-amyloid in Alzheimer’s disease APP A673T variant carriers

“Decreased plasma β-amyloid in the Alzheimer’s disease APP A673T variant carriers” has been published in the journal Annals of Neurology. This work was supported in part by JPND through the EADB project, selected in the 2015 JPco-fuND call.

In Huntington’s disease, traffic jams in the cell’s control center kill brain cells

Working with mouse, fly and human cells and tissue, researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell’s control center — the nucleus — appear to be a direct cause of…

Antibody helps detect protein implicated in Alzheimer’s, other diseases

A team of researchers has found a way to measure tau levels in the blood. The method accurately reflects levels of tau in the brain that correlate with neurological damage. The study, in mice and a small group of people,…

Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders

“Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders” has been published in the journal Clinical Epigenetics. This work was supported in part by JPND through the EPI-AD project, selected in the 2015 JPco-fuND call.

Influence of arterial hypertension, type 2 diabetes and cardiovascular risk factors on ALS outcome

“Influence of arterial hypertension, type 2 diabetes and cardiovascular risk factors on ALS outcome: a population-based study“ has been published in the journal Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. This work was supported in part by JPND through the STRENGTH project,…

Silent seizures recorded in the hippocampus of two patients with Alzheimer’s disease

A team of researchers has identified silent, seizure-like activity in the hippocampus, a brain structure significantly affected in Alzheimer’s Disease, in two patients with Alzheimer’s disease and no known history of seizures. These alterations in the brain’s electrical activity could…

Point mutations in TDP-43’s N-terminal domain compromise its stability, dimerization and functions

“Point mutations in transactive response DNA-binding protein 43 (TDP-43)’s N-terminal domain compromise its stability, dimerization and functions “ has been published in the Journal of Biological Chemistry. This work was supported in part by JPND through the RiMod-FTD project, selected in…

Low levels of ‘memory protein’ linked to cognitive decline in Alzheimer’s disease

Working with human brain tissue samples and genetically engineered mice, researchers report that consequences of low levels of the protein NPTX2 in the brains of people with Alzheimer’s disease (AD) may change the pattern of neural activity in ways that…

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