Cohort – Seniors Quid

Cohort – Seniors Quid

PAQUID

• France

http://www.isped.u-bordeaux2.fr/

[email protected]

CNSA BEAUFOUR IPSEN, NOVARTIS PHARMA

• Alzheimer’s disease and other dementias
• Parkinson’s disease

• Already possible

Studying brain and functional aging after 65 years, distinguish the normal and pathological conditions, and identify people at high risk of physical or mental deterioration in which preventive action could be possible

Representative cohort of the French population aged 65 and over

151

Risk factor for dementia and Alzheimer’s disease (social support, reactivation of herpes viruses, leisure)
Natural history of Alzheimer’s disease
Risk factor for Parkinson’s disease

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Auriacombe, S., N. Lechevallier, et al. (2006). “A longitudinal study of quantitative and qualitative features of category verbal fluency in incident Alzheimer’s disease subjects: results from the PAQUID study.” Dement Geriatr Cogn Disord 21(4): 260-266.

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Barberger-Gateau, P., D. Commenges, et al. (1992). “Instrumental activities of daily living as a screening tool for cognitive impairment and dementia in elderly community dwellers.” J Am Geriatr Soc 40(11): 1129-1134.

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Barberger-Gateau, P., C. Fabrigoule, et al. (1999). “Functional impairment in instrumental activities of daily living: an early clinical sign of dementia?” J Am Geriatr Soc 47(4): 456-462.

Barberger-Gateau, P., C. Fabrigoule, et al. (1999). “Neuropsychological correlates of self-reported performance in instrumental activities of daily living and prediction of dementia.” J Gerontol B Psychol Sci Soc Sci 54(5): P293-303.

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Bourdel-Marchasson, I., B. Dubroca, et al. (2000). “Incidence and predictors of drug-treated diabetes in elderly French subjects. The PAQUID Epidemiological Survey.” Diabet Med 17(9): 675-681.

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Dartigues, J. F., M. Gagnon, et al. (1992). “Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid).” Am J Epidemiol 135(9): 981-988.

Dartigues, J. F., M. Gagnon, et al. (1992). “Occupation during life and memory performance in nondemented French elderly community residents.” Neurology 42(9): 1697-1701.

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de Rijk, M. C., C. Tzourio, et al. (1997). “Prevalence of parkinsonism and Parkinson’s disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson’s disease.” J Neurol Neurosurg Psychiatry 62(1): 10-15.

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Persons aged 65 and over living at home and enrolled as voters in the Dordogne or Gironde

People not living at home

• 1,000 – 5,000 participants

age, sex, level of education, city of residence

Dementia and dependency, mortality

• Prospective cohort

• Age
• Sex
• Co-morbidities
• Cognitive function
• Physical ability

• No

01-01-1988

01-01-2018

• Data collection ongoing
• Data analysis ongoing
• Closed to new patients

• No

• Only through the study

• No

No

• No policy exists

No

• No