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Title of project or programme
| Title of PI | Development and validation of functional cell therapies for Huntington’s and Parkinson’s diseases |
Principal Investigators of project/programme grant
| Title | Forname | Surname | Institution | Country |
| Professor | Stephen | Dunnett | Cardiff University | UK |
Address of institution of lead PI
| Institution | Cardiff University |
| Street Address | Cardiff School of Biosciences, Life Sciences Building, Museum Avenue |
| City | Cardiff |
| Postcode | CF10 3AX |
Country
- United Kingdom
Source of funding information
Medical Research Council
Total sum awarded (Euro)
1867100.12
Start date of award
01-02-2006
Total duration of award in months
60
The project/programme is most relevant to
- Parkinson’s disease
- Huntington’s disease
Keywords
Research abstract in English
The UK is taking an international lead in developing stem cells for cell-based therapy applicable to a broad range of diseases. However, for these new sources of cells to come to effective application in the clinic requires that they are first evaluated and validated for specificity and functional potential in appropriate model systems, both in vitro and in vivo.
The proposed project establishes quality-controlled processing of cells in vitro, determines optimal dissection, preparation handling and transplantation protocols, develops the experimental models for functional analysis, and refines our understanding of the theoretical principles and mechanisms of function for application of cell-based therapies in two specific human neurodegenerative diseases, Huntington’s and Parkinson’s. The programme sustains a centre of expertise developing the quality-controlled facilities necessary to progress specific cell sources (fetal now, expanded progenitors imminently, and stem cells in the foreseeable future) to clinical application rapidly and efficiently.
Lay summary
In which category does this research fall?
- Basic research
Development and validation of functional cell therapies for Huntington’s and Parkinson’s diseases
Investments > €500k
United Kingdom
Huntington’s disease|Parkinson’s disease & PD-related disorders
2011