Molecular studies of synaptic vescicle recycling in health and disease (SYNAPSEFUNCTION)

Title of project or programme
Molecular studies of synaptic vescicle recycling in health and disease (SYNAPSEFUNCTION)
Principal Investigators of project/programme grant

Address of institution of lead PI

Country
Belgium
Source of funding information
European Research Council
Total sum awarded (Euro)
1500000
Start date of award
01-01-2011
Total duration of award in months
60
The project/programme is most relevant to

• Parkinson’s disease

Keywords

Research abstract in English
Synaptic transmission is of paramount importance for neuronal circuit integrity; if synapses fail, circuits fail. Transmission of electrical pulses in our brain is critical for normal but also higher brain functions such as learning, memory formation and thought, and understanding the regulatory processes of synaptic transmission may provide insight into neurological and psychiatric disorders, such as Parkinson’s disease, bipolar disorder and drug addiction that arise from defects in specific neuronal circuits in the brain. Here, we propose to study novel regulatory mechanisms that operate at the synapse and have the capacity to be major regulators of synaptic plasticity. Our work will include studies of novel synaptic organelles and alternative pathways of synaptic vesicle endocytosis (e.g. clathrin-dependent or kiss-and-run), with a clear link to human disease (e.g. Parkinson’s Disease). We will use innovative genetic screen approaches in flies and bacteria and study processes that regulate synaptic vesicle trafficking employing imaging, electrophysiology and electron microscopy with the ultimate hope of elucidating mechanisms of normal but also diseased brain function.
Lay summary

Molecular studies of synaptic vescicle recycling in health and disease (SYNAPSEFUNCTION)

Investments > €500k
Belgium
Parkinson’s disease & PD-related disorders
2011