Nanosystems for the early Diagnosis of Neurodegenerative diseases (NADINE)

Title of project or programme
Nanosystems for the early Diagnosis of Neurodegenerative diseases (NADINE)
Principal Investigators of project/programme grant

Address of institution of lead PI

Country
Denmark
Source of funding information
European Commission
Total sum awarded (Euro)
9000000
Start date of award
01-09-2010
Total duration of award in months
60
The project/programme is most relevant to

• Alzheimer’s disease and other dementias
• Neurodegenerative disease in general

Keywords

Research abstract in English
NADINE will address this challenge of a critical need for novel reliable tools for the early, differential, potentially predictive, and minimally invasive diagnosis of neurodegenerative disorders. To be widely usable, the system should be fully integrated and highly automated. It should also identify and quantify accurately a multiplicity of molecular biomarkers, as well as non-conventional supramolecular biomarkers such as nano-aggregates. Besides its obvious applications in diagnosis, this new technology will also have applications in drug development, for follow-up of complex biomarker signatures during disease evolution, and clinical trials. The scientific and technological objectives
1. Development of innovative nanoparticles for imuno-capturing and -detection
2. Improved micro-nanofluidic technologies
3. Improved electrophoretic separations and detection sensitivity on chip at the pico- or femtomolar level
4. Development of innovative microarrays on chip
5. Development of diagnostic signature approaches based on innovative bioinformatics tools 6. Integration of multimodal protein and peptide analysis in a single, fully integrated microfluidic system
7. Development of a fully integrated prototype for the minimally invasive diagnosis for neurodegenerative diseases
8. Societal and industrial objectives towards diagnostic instruments addressing major challenges in predictive medicine, and preparing next-generation bioanalysis technologies
9. Opening the route to new classes of applications not yet covered by microfluidic systems
Lay Summary

Nanosystems for the early Diagnosis of Neurodegenerative diseases (NADINE)

Investments > €500k
Denmark
Alzheimer’s disease & other dementias|Neurodegenerative disease in general
2011