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Title of the cohort
Newcastle 85+ Study
Acronym for cohort
Newcastle 85+ Study
Name of Principal Investigator
| Title | Professor |
| First name | Thomas |
| Last name | Kirkwood |
Address of institution where award is held
| Institution | Newcastle University Institute for Ageing and Health |
| Street Address | Campus for Ageing and Vitality |
| City | Newcastle upon Tyne |
| Postcode | NE4 5PL |
Country
United Kingdom
Website
www.ncl.ac.uk/iah
Contact email
[email protected]
Funding source
Medical research council
1. The cohort includes, or expects to include, incidence of the following conditions
- Alzheimer’s disease and other dementias
- Parkinson’s disease
- Neurodegenerative disease in general
When studies on the above condition(s) are expected to become possible
Already possible
2a. Stated aim of the cohort
To investigate in great detail the clinical, biological and psychosocial factors associated with ageing among a fully representative cohort all born in 1921 and aged 85 at entry.
2b. Features distinguishing this cohort from other population cohorts
High recruitment rate (72%) from target population including those living in institutions and with cognitive impairment. Very extensive multi-dimensional health assessment including a wide range of functional tests and assesments, blood-based biomarkers, activity monitoring and questionnaires, as well as review of GP records.
3a. i) Number of publications that involve use of cohort to date
6
3a. ii) Up to three examples of studies to date (PI, Institution, Title of Study)
Kirkwood, Newcastle University Institute for Ageing and Health, Health and disease in 85 year olds
Adamson, Newcastle University Institute of Health and Society, Dietary assessment in the Newcastle 85+ study
Jagger, Newcastle University Institute for Ageing and Health, Projections of future care needs
3b. Publication list/link to where data or publications are accessible (if available)
Collerton J, Barrass K, Bond J, Eccles M, Jagger C, James OFW, Martin-Ruiz C, Robinson AL, von Zglinicki T, Kirkwood TBL. The Newcastle 85+ study: biological clinical and psychosocial factors associated with healthy ageing: study protocol. BMC Geriatrics. 2007;7:14.
Collerton J, Collerton D, Arai Y, Barrass K, Eccles M, Jagger C, McKeith IG, Saxby BK, Kirkwood TBL. A comparison of the acceptability, feasibility and utility of computerised and pencil and paper tasks in assessing cognitive function in community dwelling older people in the Newcastle 85+ Pilot Study. Journal American Geriatric Psychiatry 2007;55:1630-1635.
Collerton JC, Martin-Ruiz C, Kenny A, Barrass K, Von Zglinicki T, Kirkwood TBL, et al. Telomere length is associated with left ventricular function in the oldest old: the Newcastle 85+ study. European Heart Journal 2007;28:172-176.
Adamson AJ, Collerton J, Davies K, Foster E, Jagger C, Stamp E, Mathers JC, Kirkwood TBL; Newcastle 85+ Study Core Team. Nutrition in advanced age: dietary assessment in the Newcastle 85+ study. Eur J Clin Nutr. 2009;63:S6-18.
Collerton J, Davies K, Jagger C, Kingston A, Bond J, Eccles MP, Robinson LA, Martin-Ruiz C, von Zglinicki T, James OF, Kirkwood TBL. Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study. BMJ. 2009;339:b4904.
Jagger C, Collerton JC, Davies K, Kingston A, Robinson LA, Eccles MP, von Zglinicki T, Martin-Ruiz C, James OF, Kirkwood TBL, Bond J. Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs. BMC Geriatrics 2011;11:21.
3c. Information (i.e. research findings) expected to be gained from the population cohort
4a. Study criteria: age range of participants at recruitment
| Age in years from: | 85 |
| To (‘until death’ if applicable): | 86 |
4b. Study criteria: inclusion criteria
Resident in Newcastle or North Tyneside and registered there with a GP.
Born in 1921
4c. Study criteria: exclusion criteria
None other than exclusion by GP as being in last stages of terminal illness or as posing a potential safety risk to a visiting member of the research team.
5. Size of the cohort (i.e. number of participants enrolled)
1,000 – 5,000 participants
6a. Measures used to characterise participants
6b. Additional measures for participants with a clinical disorder
No
6c. Are there defined primary and secondary endpoints (e.g. defined health parameters)
No
7. Study design
- Prospective cohort
8. Cases matched by
- Age
9a. Does the study include a specialised subset of control participants
No
9b. If yes, description of specialised subset of control participants
10a. i) Data collection start date
01-06-2006
10a. ii) Data collection end date
31-03-2011
10a iii) Data collection for this study is
- Data collection ongoing
- Data analysis ongoing
- Closed to new patients
10b. Plans to continue the cohort study beyond the current projected end date
- Yes – funding applied for
11. Data collected
- Only through the study
12. System in place to enable re-contact with patients for future studies
Yes (participants have given permission to be re-contacted via the PIs to ask if they would participate in further studies)
13a. Format and availability of data stored in a database
| Yes/No | % available | |
| Data summarised in database | Yes | 85% |
| Database is web-based | ||
| Database on spreadsheet | Yes | 85% |
| Database is on paper | ||
| Other (specify) |
Language used:
13b. Format and availability of data held as individual records
| Yes/No | % available | |
| Data held as individual records | ||
| Data is web-based | ||
| Data held on computer based records | Yes | 85% |
| Data held on cards | ||
| Other (specify) |
Language used:
14a. Are data available to other groups
Yes
14b. Access policy/mechanisms for access if data are available to other groups
- Apply to PI or co-ordinator at resource
- Access Committee mechanism
15. Data sharing policy specified as a condition of use
No requirement to make data publicly available
16a. Are tissues/samples/DNA available to other groups
Yes
16b. i) Description of available tissues/samples/DNA
- Living donors: blood derivatives
- Living donors: DNA
16b. ii) Form available tissues/samples/DNA are supplied in
- Secondary samples: plasma
- Secondary samples: DNA
16b. iii) Is the access policy/mechanism for obtaining samples the same as that for obtaining data
Yes
17. Is information on biological characteristics available to other groups
- Yes, for all the cohort
Newcastle 85+ Study
Population Cohorts
United Kingdom
Alzheimer’s disease & other dementias|Neurodegenerative disease in general|Parkinson’s disease & PD-related disorders