Prevention of Alzheimer’s Dementia in High Risk Populations: A Randomized Controlled Trial of a Combination of Cognitive Remediation and Brain Stimulation

PACt-MD
Prevention of Alzheimer’s Dementia in High Risk Populations: A Randomized Controlled Trial of a Combination of Cognitive Remediation and Brain Stimulation

http://www.camh.ca/en/research/about_research_at_CAMH/scientific_staff_profile/Pages/Benoit-Mulsant.aspx
[email protected]
Chagnon Family and Brain Canada (with financial support of Health Canada)
Chagnon Family and Brain Canada (with financial support of Health Canada)

Only through the study|Through links to medical records

Canada

Yes
Access through collaboration with PI only|Access Committee mechanism|Resource has own ethics approval so usually no need for separate external ethics approval

Yes
Living donors: blood|Living donors: DNA
Secondary samples:(derivatives of primary samples)|Secondary samples: plasma|Secondary samples: DNA
Yes
Yes, for all the cohort
Assessing whether a combination of cognitive remediation and brain stimulation prevent Mild Cognitive Impairment and Alzheimer’s Disease in 375 at-risk individuals.promising evidence of pro-cognitive effects.

1-1,000
200-500
Neuropsychological battery; CDR; IQCODE; physical and functional status
Biomarkers (DNA, head MRI/DTI/fMRI, PET amyloid, CSF)
Yes
Progression from normal cognitive status to MCI or progression from MCI to dementia
Prospective cohort|Randomized Controlled Trial|Age|sex
Co-morbidities|Cogntive function|Physical ability|Randomization

50 healthy controls (no cognitive impairment; no depression)
Data collection ongoing
Yes – intend to apply for funding

Database is web-based

Data is web-based

Prevention of Alzheimers Dementia in High Risk Populations: A Randomized Controlled Trial of a Combination of Cognitive Remediation and Brain Stimulation
Alzheimer’s disease and other dementias

Case Control Studies
Canada
Alzheimer’s disease & other dementias
2016