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BDR
Brains for Dementia Research
http://www.brainsfordementiaresearch.org.uk/
[email protected]
Alzheimer’s Research UK and Alzheimer’s Society in association with Medical Research Council
Alzheimer’s Research UK and Alzheimer’s Society in association with Medical Research Council
Data collection ongoing| Data analysis ongoing| Closed to new patients
English
United Kingdom
Primary Samples: Stabilised samples (frozen or fixed)
No
PAST HISTORY FROM CAMDEX, CLINICAL DEMENTIA RATING WORKSHEET (Study partner), BRISTOL ACTIVITIES OF DAILY LIVING SCALE (BADLS), NEUROPSYCHIATRIC INVENTORY, GLOBAL DEPRESSION SCALE (CORNELL SCALE FOR DEPRESSION IN DEMENTIA, GERIATRIC DEPRESSION SCALE), MINI MENTAL STATE EXAMINATION, TICS-M, MONTREAL COGNITIVE ASSESSMENT, MoCA-Blind, CLINICAL DEMENTIA RATING WORKSHEET (Participant), HEARING AND EYESIGHT IMPAIRMENT, OTHER PHYSICAL PARAMETERS (BLOOD PRESSURE, WAIST/HIP RATIO, GLOBAL DETERIORATION SCALE, HACHINSKI ISCHAEMIC SCORING SYSTEM, LIFESTYLE (DIET & EXERCISE)
No
Yes – intend to apply for funding
Alzheimer’s disease and other dementias
Data is held as individual records
No
No
No
Yes
Apply to PI or co-ordinator at resource| Access independent of collaboration with PI| Access committee mechanism| Local/regional access| National access| International access| Access to industry| Access for pilot studies permitted| Resource has own ethics approval so usually no need for separate external ethics approval
No requirement to make data publicly available
Yes
Yes
To supply brain tissue and associated cognitive data for research to the neuroscience community, exercising responsible stewardship for the brain tissue and maximizing the potential benefit of this precious resource.
This cohort contains a high proportion of registered brain donors without dementia. Participants undergo regular cognitive testing and blood samples are also collected from some of the cohort.
161
A Olmos-Alonso, University of Southampton, Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology| Rita Guerreiro, UCL, Genome-wide analysis |of genetic correlation in dementia with Lewy bodies, Parkinsons and Alzheimers diseases |Katie Lunnon, University of Exeter, Methylomic profiling implicated cortical deregulation of ANK1 in Alzheimers disease.
1,000-5,000 participants
Prospective cohort|Longitudinal
No
05/01/2008
04/01/2018
Data collection ongoing| Data analysis ongoing| Closed to new patients
Only through the study
Data summarised in database
No
No
No
Brains for Dementia Research
Already possible
Population Cohorts
United Kingdom
Alzheimer’s disease & other dementias
2016