Transgenic HD Minipig (TgHD, PIGMOD Center)

Czech Republic

At present, we are probably the only facility to be breeding TgHD minipigs. We have four generations, around 180 animals. The animals are beiing studied for phenotype development, and also first preclinical testing with a pharmaceutical company Uniqure is beeing done. We hope to attract more companies for testing their therapeutic treatment on this unique large animal model for Huntingon’s disease. Funded by CHDI, Czech-Norwegian Research Programme 7F14308, National Programme of Sustainibility LO1609
Huntington’s disease
Animals| Other – animal-derived embryonic neural stem cells
Yes
Apply to PI or co-ordinator at resource|Access through collaboration with PI only|International access
Yes
Under MTA with CHDI
Other – TgHD and control animal derived

HD
Minipigs
Yes
Male fertility failure at 13 months, At two years: fragmentation of Htt in brain, and testes, neuroinflamation, decrease in total creatine in thalamus, At two years: fragmentation of Htt in brain, and testes, neuroinflamation, decrease in total creatine in thalamus, At four years: mitochondria impairment in heart and muscles, At five years: starting biohavioral and motoric problems based on three available pairs at this age
Four generations of minipigs with N-terminal part of human mutated (128Q,523AA)HTT expressed under the human promoter at chromosome 1 (1q24-q25) of porcine DNA and their wild type sibling.

Yes
2020
15-20

Experimental Models
Czech Republic

2016