This website is now the new JPND's archival platform. This website hosts all of JPND's archived content and resources.
Please continue to visit this site to access publications, videos and reports from JPND's activities.
ArcAbeta Mouse (University of Zurich +ETH)
www.pi.ethz.ch
[email protected]
Switzerland
ArcAbeta Mouse (University of Zurich +ETH)
The arcAbeta mouse belongs to the family of amyloid precursor protein expressing mouse lines. It shows age-dependent amyloid pathology with a strong vascular phenotype. Cognitive deficits can be detected by behavioral tests of hippocampal-dependent memory formation.
Alzheimer’s disease and other dementias
Animals
Yes
Apply to PI or co-ordinator at resource| Access through collaboration with PI only| International Access
No
Not applicable
AD
Rat
Yes
Intracellular punctate deposits of amyloid. Amyloid plaque formation and cerebral amyloid angiopathy. Robust cognitive impairment starting at 5 months of age
express human APP with the combined Swedish and Arctic mutations
No
Not determined
Experimental Models
Switzerland
2016