Microglia Cell Model (VU University Medical Center)

The Netherlands

Microglia, isolated from post mortem human brain (obtained from the Netherlands Brain Bank) , are used to compare effects of Alzheimer’s, Parkinson’s disease and fronto-temporal dementia specific misfolded proteins on inflammasome activation, and to study mechanisms of activation and effects of potential therapeutics. Although culturing protocols are estabished, supply of tissue is a limiting factor, as are the relative low yield in cells and the fact that microglial cells have to be used within 10 days after isolation, and are vulnerable (transport/ cannot be stored frozen).
Alzheimer’s disease & other dementias| Parkinson’s disease & PD-related disorders| Prion disease
Microglia, isolated from post mortem human brain
Yes
Access through collaboration with PI only
No

Patient derived

JPND “InCure” project.
Yes
2018
NA; (resource is infrastructure)
No

Experimental Models
Netherlands

2016