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The ICICLE-PD study aims to accurately characterise two independent cohorts of incident parkinsonism in Newcastle-Gateshead and Cambridgeshire. A key objective is to identify patients who develop Parkinson’s disease dementia (PDD) and the factors that predict its evolution. From this information, a simplified panel of tests that can be used to predict PDD will be established. ICICLE-PD will therefore provide a platform for studies investigating agents designed to help treat this complication of PD. Participants were recruited between June 2009 and March 2012. Longitudinal follow up is on going with assessments in person at 18-month intervals.
Last update: 16/01/2017
Types Neurodegenerative disease-specific cohort
Participant Types Condition diagnosed
Countries United Kingdom
Genders Male and Female
Sample sizes 0 to 4,999
Ages 10 to 19|20 to 39
Brain related measures Cognitive function|Mental health|Neurological
Funtional rating Caregiver|Individual physiological
Anthropometric Blood pressure|Height|Hip circumference|Waist circumference|Weight
Physical Cardiovascular|Hearing and Vision
Biological samples Blood|Cerebral spinal fluid (CSF)>CSF biomarker data available
Genotyping Gene screening
Brain imaging Magnetic resonance imaging (MRI)|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking Consent for brain donation
Lifestyle Alcohol|Physical activity|Smoking
Socio-economic Education|Housing and accommodation|Marital status|Occupation and employment|Unpaid care
Health service utilisation
Institute names Newcastle University
Current Sample Sizes 0 to 4,999
age at recruitment >18
last updated
recruitment period Jun 09-Mar12
estimated current sample size number value 318
cohort acronym ICICLE-PD
start date Jun 09-Mar12
pi Professor David Burn
website http://www.ncl.ac.uk/caru/about
contact details Clinical Ageing Research Unit
Campus for Ageing and Vitality
Newcastle upon Tyne
NE4 5PL
abstract The ICICLE-PD study aims to accurately characterise two independent cohorts of incident parkinsonism. 318 participants over 18 were recruited between June 2009 and March 2012.
funders Parkinson’s Disease Society
Rhoda Lockhart Parkinson’s Disease Research Fund
contact email Alison Yarnall Email: [email protected] and Rachel Lawson Email: : [email protected]
contact phone number ‘+44 (0)191 2081279 and +44 (0) 191 2081277
estimated current sample size 0 to 4,999
sample sizes 318