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The AMPLE study has been set up to investigate differences and outcomes in those with Lewy body dementia with and without concurrent Alzheimer’s disease/pathology. The principle aim of AMPLE is to undertake amyloid PET imaging in Lewy Body Dementia (LBD) and Alzheimer’s disease (AD) of 80 participants over the age of 60 and investigate the distribution of amyloid burden in LBD relative to AD and controls at baseline. A further aim is to determine the relationship between amyloid levels at baseline, clinical features of the disease, other imaging changes and subsequent clinical course in follow up.
Primary analysis would divide LBD patients into high and low amyloid burden with participants then compared on clinical features with AD-like symptoms and cognitive profiles. Follow up will be completed annually through surveys and clinical examinations.
Last update – 01/02/2017
Types Rare neurodegenerative condition
Participant Types Condition diagnosed
Countries United Kingdom
Genders Male and Female
Sample sizes 0 to 4,999
Ages 60 to 100
Brain related measures Behaviour|Cognitive function|Mental health
Funtional rating Individual physiological|Individual psychological
Anthropometric
Physical Cardiovascular|Hearing and Vision
Biological samples Blood|Cerebral spinal fluid (CSF)
Genotyping Gene screening
Brain imaging Magnetic resonance imaging (MRI)|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking
Lifestyle Alcohol|Smoking
Socio-economic Education
Health service utilisation
Institute names Newcastle University
Current Sample Sizes 0 to 4,999
age at recruitment >60
last updated
recruitment period 2013
estimated current sample size number value
cohort acronym AMPLE
start date 2013
pi Professor John O’Brien
website http://www.ncl.ac.uk/caru/research/project/5055
contact details Clinical Ageing Research Unit, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL
abstract AMPLE is disease specific cohort which recruited in 2013 80 participants with Lewy body dementia with and without concurrent Alzheimers disease/pathology. Its aim is to investigate the distribution of amyloid burden in LBD relative to AD.
funders NIHR Newcastle Biomedical Research Unit|Avid
contact email [email protected];[email protected]
contact phone number +44 (0) 191 208 1322
estimated current sample size
sample sizes 80