Southall and Brent Revisited

The Southall And Brent Revisited Study (SABRE) is the largest tri-ethnic population-based cohort in the UK, involving nearly 5000 European, Indian Asian and African Caribbean men and women. It investigates the causes of diabetes and disorders of the heart and circulation and examines underlying reasons for ethnic differences in risk of these disorders.

The participants were aged 40-69 when first studied between 1989 and 1991. In 2008-2011 a comprehensive combined morbidity and mortality follow up was carried out, together with non-invasive clinical measurements in order to quantify sub-clinical disease. SABRE visit 2 tested hypotheses generated from the Southall and Brent baseline studies and ongoing mortality follow-up.

SABRE Visit 3 (25 year follow-up visit) started in July 2014 and is collecting data on index participants and new participants, including partners of index participants. The focus of this visit is on cardiac, cognitive and physical function in older age, in association with mid-life risk factors. Ethnic and gender differences in function will also be examined.

Last update – 10/04/2017

Types General population-based cohort
Participant Types No diagnosis
Countries United Kingdom
Genders Male and Female
Sample sizes 0 to 4,999
Ages 40 to 59|60 to 100
Brain related measures Cognitive function|Mental health|Neurological
Funtional rating Caregiver|Individual physiological|Individual psychological
Anthropometric Blood pressure|Height|Hip circumference|Waist circumference|Weight
Physical Cardiovascular|Hearing and Vision|Musculoskeletal|Respiratory
Biological samples Blood|Saliva|Urine
Genotyping Gene screening
Brain imaging Magnetic resonance imaging (MRI)
Brain banking
Lifestyle Alcohol|Dietary habits|Physical activity|Smoking
Socio-economic Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care
Health service utilisation Formal health and social care service utilisation including private care
Institute names University College, London
Current Sample Sizes 0 to 4,999

age at recruitment 40-69
last updated
recruitment period 1988
estimated current sample size number value 2572
cohort acronym SABRE
start date 1988
pi Professor Nish Chaturvedi
website http://www.sabrestudy.org
contact details UCL Institute of Cardiovascular Science,
Gower Street,
London,
WC1E 6BT
abstract  SABRE is a population based cohort looking at the reasons for ethnic differences in risk of developing heart disorders or diabetes. 4,858 ethnically diverse participants aged betweem 40-69 were recruited in 1989.
funders  Wellcome Trust
British Heart Foundation
contact email Email: [email protected]| PI Email: [email protected]
contact phone number 02076 799471
estimated current sample size 0 to 4,999
sample sizes 4859