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TRACK-HD was a prospective observational biomarker study in participants with premanifest and early Huntington’s disease (HD). Track-HD assessed longitudinal data collected at baseline, 12 months, 24 and 36 months at sites in Leiden (Netherlands), London (UK), Paris (France), and Vancouver (Canada). Participants were individuals without HD but carrying the mutant HTT gene (ie, premanifest HD), patients with early HD, and healthy control individuals matched by age and sex to the combined HD groups. Data were collected with 3T MRI, clinical, cognitive, quantitative motor, oculomotor, and neuropsychiatric assessments. TrackOn-HD followed on from TRACK-HD aiming to investigate compensatory mechanisms in premanifest gene carriers. Baseline, 12 and 24 month data was collected from the same four sites on premanifest gene carriers and healthy controls including 3T MRI, task and resting state fMRI, DTI, clinical, cognitive, quantitative motor and neuropsychiatric assessments.
Last update – 11/04/2017
Types Neurodegenerative disease-specific cohort
Participant Types Condition diagnosed
Countries United Kingdom
Genders Male and Female
Sample sizes 0 to 4,999
Ages 10 to 19|20 to 39|40 to 59|60 to 100
Brain related measures Behaviour|Cognitive function|Mental health|Neurological
Funtional rating Individual physiological|Individual psychological
Anthropometric Height|Weight
Physical Cardiovascular|Hearing and Vision
Biological samples Blood
Genotyping Gene screening
Brain imaging Magnetic resonance imaging (MRI)|Single photon emission computerised tomography (SPECT)
Brain banking
Lifestyle Alcohol|Smoking
Socio-economic Education|Ethnic group|Housing and accommodation|Occupation and employment
Health service utilisation
Institute names University College, London
Current Sample Sizes 0 to 4,999
age at recruitment 18-65
last updated
recruitment period Phase 1: 2008-2011 Phase 2: 2012-2014
estimated current sample size number value 430
cohort acronym
start date 2008-2011|2012-2014
pi Professor Sarah Tabrizi
website http://hdresearch.ucl.ac.uk/completed-studies/trackon-hd/ http://hdresearch.ucl.ac.uk/our-results/track-hd/
contact details CHDI Management, Inc.
155 Village Boulevard, Suite 200
Princeton, NJ 08540
Office: 609-945-9586
abstract TRACK HD was the forerunning cohort of TrackOn, both focused on participants with premanifest and early HD. 366 gene carriers were recruited as part of TRACK HD between 2012-2014 aged of 18-65.
funders CHDI Foundation
contact email [email protected]| PI Email: [email protected]
contact phone number 609-945-9586
estimated current sample size 0 to 4,999
sample sizes 366