Constances Cohort

The CONSTANCES general-purpose cohort is intended to serve as an epidemiological research infrastructure accessible to the epidemiologic research community with a focus on chronic diseases and aging. CONSTANCES is designed as a randomly selected representative sample of French adults aged 18-69 years at inception; 200,000 subjects will be included over a five-year period. At inclusion, the selected subjects are invited to complete questionnaires and to attend a Health Screening Clinic (HSC) for a comprehensive health examination. A biobank will be set up. The follow-up includes a yearly self-administered questionnaire, and a periodic visit to an HSC. Social and health data are collected from the French national databases. Data collected for participants include social and demographic characteristics, socioeconomic status, life events, behaviors, and occupational factors. The health data cover a wide spectrum: self-reported health scales, reported prevalent and incident diseases, long-term chronic diseases and hospitalizations, sick-leaves, handicaps, limitations, disabilities and injuries, healthcare utilization and services provided, and causes of death. To take into account non-participation at inclusion and attrition throughout the longitudinal follow-up, a cohort of non-participants was set up and will be followed through the same national databases as participants.

Last update – 20/06/2017

Types General population-based cohort
Participant Types No diagnosis
Countries France
Genders Male and Female
Sample sizes 100,000 to 499,999
Ages 10 to 19|20 to 39|40 to 59|60 to 100
Brain related measures Behaviour|Cognitive function|Mental health|Neurological
Funtional rating Individual psychological
Anthropometric Blood pressure|Height|Hip circumference|Waist circumference|Weight
Physical Cardiovascular|Musculoskeletal|Respiratory
Biological samples Blood
Genotyping Gene screening
Brain imaging
Brain banking Consent for brain donation
Lifestyle Alcohol|Dietary habits|Physical activity|Smoking
Socio-economic Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Marital status|Occupation and employment|Unpaid care
Health service utilisation Formal health and social care service utilisation including private care
Institute names Inserm UMS 11 – Population-Based Cohort Unit
Current Sample Sizes 100,000 to 499,999

age at recruitment 18-69
last updated
recruitment period 2012-2019
estimated current sample size number value 143000
cohort acronym
start date 2012-2019
pi Dr. Marie Zins
website http://www.constances.fr/index_EN.php
contact details Paris Descartes Medical School – Paris, France
abstract  CONSTANCES is a population cohort focused on chronic diseases and aging. 200,000 subjects between 18-69 will be recruited over a 5 year period which began in 2012.
funders  French Agence Nationale de la Recherche
contact email [email protected]
contact phone number +33177747428
estimated current sample size 100,000 to 499,999
sample sizes 200000