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The EADC-PET project (EAPP, The European Alzheimer’s Disease Consortium PET project) is a spontaneous multicentric study (ProtocolDraftSep2008; ProtocolDraftFeb2009) involving at the moment five Centres in four Countries (CENTRES), belonging to the EADC consortium. It was launched during the EADC meeting in Amsterdam, during fall 2007, by Flavio Nobili (Genoa) who is the Principal Investigator.
The project aims at sharing FDG-PET, MRI, neuropsychological, genetic, EEG and clinical information of patients with amnestic Mild Cognitive Impairment (aMCI) and matched healthy controls. Information is uploaded in a safe FTP facility on the server of University of Genoa. Username and password have been provided to all participants. Use of data is regulated by a ‘Confidentiality Disclosure Agreement’ that can be downloaded from this web site (Confidential_Disclosure_Agreement). The Centres propose original studies by sending a formal proposal to all participants who can agree or disagree, or propose modifications/suggestions to the original proposal.
The objective is to follow-up aMCI patients with clinical and neuropsychological examinations to pick up conversion to Alzheimer’s dementia or to other forms of dementia. FDG-PET can be analyzed by means of several post-processing strategies to highlight glucose metabolic information and to identify the characteristics of what is today called ‘prodromal’ AD.
Last Update 21/09/2017
Types Neurodegenerative disease-specific cohort
Participant Types At-risk diagnosis
Countries France|Germany|Italy|Netherlands
Genders Male and Female
Sample sizes 0 to 4,999
Ages 10 to 19|20 to 39|40 to 59|60 to 100
Brain related measures Cognitive function|Mental health|Neurological
Funtional rating Individual psychological
Anthropometric
Physical
Biological samples Cerebral spinal fluid (CSF)>CSF biomarker data available
Genotyping Gene screening
Brain imaging Magnetic resonance imaging (MRI)|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking
Lifestyle
Socio-economic Education
Health service utilisation
Institute names Multiple
Current Sample Sizes 0 to 4,999
age at recruitment >18
last updated
recruitment period 2009-2012
estimated current sample size number value
cohort acronym (EADC) – (EAPP)
start date 2009-2012
pi Flavio Nobili
website http://www.eadc.info/sito/pagine/a_07.php?nav=a
contact details Clinical Neurology, Dept of Neuroscience (DINOGMI), Univ of Genoa, Largo Daneo, 3
I-16132 Genoa, Italy
abstract EADC-PET is a multicentric study which was launched in 2007. 142 participants over 18 years of age were recruited with the objective of following MCI patients with clinical and neuropsychological examinations.
funders
contact email PI Email: [email protected]
contact phone number +39 010 3537568
estimated current sample size
sample sizes 142