Leipzig Longitudinal Study of the Aged

LEILA75+ is a prospective population-based cohort study on the epidemiology of dementia and other neurodegenerative disorders. The main aims of the study included to determine a) the prevalence and incidence of dementia as well as subtypes of dementia, b) the prevalence and incidence of mild cognitive impairment (MCI) and c) the occurrence of other related conditions, such as subjective cognitive decline (SCD). Likewise, it was aimed at identifying risk factors and groups of high-risk-individuals for the development of dementia, MCI and SCD.

Overall, 1,692 individuals of at least 75 years of age (from private households as well as from institutions) were approached via random selection from the registry office of the city of Leipzig (response rate: 81%). Finally, the LEILA75+ cohort consisted of 1,265 individuals at baseline. Data collection took place at participants homes through structured interviews (incl. socio-demographic variables, a cognitive test battery/SIDAM, functional and psychosocial assessments, medical conditions). If participants’ were not able to complete assessments, proxy information was gathers from relatives. After baseline assessment in 1997/1998, 5 follow-up waves were conducted every 1.5 years. Additionally, a long-term follow-up was performed 15 years after baseline.

Further study details have been published in:
Riedel-Heller SG, Busse A, Aurich C, Matschinger H, Angermeyer MC. Prevalence of dementia according to DSM-III-R and ICD-10: results of the Leipzig Longitudinal Study of the Aged (LEILA75+) Part 1. British Journal of Psychiatry 2001; 179: 250-254.

Riedel-Heller SG, Busse A, Aurich C, Matschinger H, Angermeyer MC. Incidence of dementia according to DSM-III-R and ICD-10: results of the Leipzig Longitudinal Study of the Aged (LEILA75+), Part 2. British Journal of Psychiatry 2001; 179: 255-260.

Riedel-Heller S, G, Schork A, Matschinger H, Angermeyer M, C, Recruitment Procedures and Their Impact on the Prevalence of Dementia. Neuroepidemiology 2000;19:130-140.

Types General population-based cohort
Participant Types No diagnosis
Countries Germany
Genders Male and Female
Sample sizes 0 to 4,999
Ages 60 to 100
Brain related measures Cognitive function|Mental health|Neurological
Funtional rating Individual physiological|Individual psychological
Anthropometric Blood pressure
Physical Cardiovascular|Hearing and Vision
Biological samples
Genotyping Gene screening
Brain imaging
Brain banking
Lifestyle Alcohol|Smoking
Socio-economic Education|Ethnic group|Family circumstances|Housing and accommodation|Informal support|Marital status|Occupation and employment
Health service utilisation Formal health and social care service utilisation including private care
Institute names Institute of Social Medicine, Occupational Medicine and Public Health (ISAP), Medical Faculty, University of Leipzig, Leipzig, Germany
Current Sample Sizes 0 to 4,999

age at recruitment >75
last updated
recruitment period 1997-2013
estimated current sample size number value
cohort acronym LEILA75+
start date 1997-2013
pi Prof. Steffi G. Riedel-Heller, MPH
website http://isap.uniklinikum-leipzig.de
contact details Dr. Susanne Roehr, M.Sc.
Institute of Social Medicine, Occupational Health and Public Health (ISAP)
Medical Faculty, University of Leipzig
Philipp-Rosenthal-Straße 55
04103 Leipzig
Germany
abstract  LEILA75+ is a prospective population-based cohort study on the epidemiology of dementia and other neurodegenerative disorders. Overall, 1,692 individuals of at least 75 years of age were recruited between 1997-2013.
funders  Bundesministerium für Bildung und Forschung (BMBF/Federal Ministry of Education and Research)
contact email Email: [email protected]
contact phone number Tel: +49 (0) 341 97 15410
estimated current sample size
sample sizes 1265