The Limache cohort

The Limache cohort was set up to assess the programming and life course events hypotheses in relation to cardiovascular risk factors and chronic respiratory conditions, especially asthma, in the context of an unprecedented economic growth in Chile. The cohort was a representative sample of 1,232 participants born between 1974 and 1978 in the hospital of Limache. The study includes data collected at birth, during the 1st year of life, at 22 to 28 years (collected between 2000 and 2002) and at 32 to 38 years (collected between 2010 and 2012).

This was possible because details were collected for all births in the country including duration of gestation, birthweight and birth length. Limache, a semirural agricultural area relatively near Santiago and close to Viña del Mar and Valparaíso, was chosen because: a birth register in the hospital has been kept since the 1970s; paediatric clinical records were kept in the local hospital ; and there was demographic information that emigration from this area was low so that we would be able to find most participants born in the 1970s still living in Limache and in Olmué, a neighbouring area.

Types General population-based cohort
Participant Types No diagnosis
Countries Chile
Genders Male and Female
Sample sizes 0 to 4,999
Ages 20 to 39|40 to 59|60 to 100
Brain related measures
Funtional rating
Anthropometric Blood pressure|Height|Waist circumference|Weight
Physical Cardiovascular|Respiratory
Biological samples Blood
Genotyping
Brain imaging
Brain banking
Lifestyle Alcohol|Dietary habits|Physical activity|Smoking
Socio-economic Family circumstances|Housing and accommodation|Income and finances|Informal support|Occupation and employment
Health service utilisation
Institute names University of Chile
Current Sample Sizes 0 to 4,999

age at recruitment >22
last updated
recruitment period 1999
estimated current sample size number value
cohort acronym
start date 1999
pi Hugo Amigo, Patricia Bustos
website https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121550/
contact details Department of Nutrition,
Faculty of Medicine,
University of Chile,
Independencia 1027
Santiago
Chile
abstract  The Limache cohort was set up to assess the programming and life course events hypotheses in relation to cardiovascular risk factors and chronic respiratory conditions, especially asthma, in the context of an unprecedented economic growth in Chile. The Limache cohort has 1,232 participants
funders  Wellcome Trust, National Research Fund of Chile
contact email PI Email (Chile): [email protected]; [email protected]; PI Email (Kings College London): [email protected]
contact phone number Tel: +56 2 2978 6213
estimated current sample size
sample sizes 1,232