The Moli-sani Study

The Moli-sani study (www.moli-sani.org) is a cohort study aiming at evaluating the risk factors (environmental, genetics, bio-molecular) linked to chronic-degenerative disease with particular regard to cancer, cardiovascular, cerebrovascular and neurodegenerative disease.
The study has recruited, between March 2005 and April 2010, 24,325 people aged ³ 35 living in the Molise region, from city hall registries by a multistage sampling. Exclusion criteria were pregnancy at the time of recruitment, disturbances in understanding or willingness, current poly-traumas or coma, or refusal to sign the informed consent. Participation rate was 70%.
All subjects underwent electrocardiogram and spirometric tests aimed to evaluate pulmonary diffusion capacity, gas diffusion and pulmonary volumes through plethysmography.
The European Prospective Investigation into Cancer and Nutrition FFQ was used to determine daily nutritional intakes consumed in the past year.
A follow-up based on linkage with hospital discharge records (SDO) and mortality regional registry was performed at December 2011 with a median of 4.3 years and at December 2014 with a median of 9.6 years. Outcomes analysed at follow-up are: mortality for any and specific causes, hospitalization and hospital stay, coronary artery disease, stroke, atrial fibrillation, heart failure, diabetes, cancer.

Types General population-based cohort
Participant Types No diagnosis
Countries Italy
Genders Male and Female
Sample sizes 20,000 to 49,999
Ages
Brain related measures
Funtional rating Individual psychological
Anthropometric Blood pressure|Height|Hip circumference|Waist circumference|Weight
Physical Cardiovascular|Musculoskeletal|Reproductive
Biological samples Blood|Urine
Genotyping Gene screening
Brain imaging
Brain banking
Lifestyle Alcohol|Dietary habits|Physical activity|Smoking
Socio-economic Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment
Health service utilisation Formal health and social care service utilisation including private care
Institute names IRCCS Istituto Neurologico Mediterraneo – NEUROMED
Current Sample Sizes 20,000 to 49,999

age at recruitment >35
last updated
recruitment period 2005-2010
estimated current sample size number value 24,325
cohort acronym
start date 2005-2010
pi Prof. Licia Iacoviello and Prof. Giovanni de Gaetano
website http://www.moli-sani.org
contact details Via dell Elettronica
86077 Pozzilli (IS).
Italy
abstract  The Moli-sani study is a cohort study aiming at evaluating the risk factors linked to chronic-degenerative disease with particular regard to cancer, cardiovascular, cerebrovascular and neurodegenerative disease. The Moli-sani study has recruited 24,325 participants
funders  Pfizer Italia Foundation and Italian Ministry of University and Research (MIUR)
contact email [email protected]; PI email: [email protected]; [email protected]
contact phone number 
estimated current sample size
sample sizes 25,000