Hisayama Study

A population-based prospective study of cerebro-cardiovascular diseases was begun in 1961 in the town of Hisayama, a suburb of the Fukuoka metropolitan area of Kyushu Island in Japan. In addition, comprehensive surveys of cognitive impairment in the elderly of this town have been conducted since 1985. In 1988, a total of 1,228 residents aged ?60 years (91.1% of the total population in this age group) participated in a screening examination for the present study. After exclusion of 33 subjects who had dementia, 90 who had already had breakfast, 5 who were on insulin therapy, and 81 who could not complete the OGTT, a total of 1,019 subjects without dementia underwent the OGTT. From a total of 1,019 subjects, 2 who died before starting follow-up were excluded, and the remaining 1,017 subjects (437 men and 580 women) were enrolled in this study.

The subjects were followed up prospectively for 15 years, from December 1988 to November 2003 (mean 10.9 years; SD 4.1 years).

Types Neurodegenerative disease-specific cohort
Participant Types No diagnosis
Countries Japan
Genders Male and Female
Sample sizes 0 to 4,999
Ages 60 to 100
Brain related measures
Funtional rating Individual physiological
Anthropometric Blood pressure|Height|Waist circumference|Weight
Physical Cardiovascular|Respiratory
Biological samples Blood
Genotyping Gene screening
Brain imaging Magnetic resonance imaging (MRI)
Brain banking Consent for brain donation
Lifestyle Alcohol|Dietary habits|Physical activity|Smoking
Socio-economic Education|Occupation and employment
Health service utilisation
Institute names Kyushu University
Current Sample Sizes 0 to 4,999

age at recruitment > 60
last updated
recruitment period 1985-2017
estimated current sample size number value
cohort acronym
start date 1985-2017
pi Professor Toshiharu Ninomiya
website http://www.epi.umn.edu/cvdepi/study-synopsis/hisayama-study/
contact details Department of Epidemiology and Public Health,
Graduate School of Medical Sciences,
Kyushu University Fukuoka,
Japan
abstract  A population-based prospective study of cerebro-cardiovascular diseases was begun in 1961 in the town of Hisayama, Japan. The subjects were followed up prospectively for 15 years, from December 1988 to November 2003.
funders  The Ministry of Education, Culture, Sports, Science and Technology of Japan, Ministry of Health, Labour and Welfare of Japan
contact email [email protected]; [email protected]
contact phone number 
estimated current sample size
sample sizes 3,000