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General Information
Mouse: FVB/N x 129S6/SvEvTac
Expression of the wild type human alpha-synuclein protein using the P1 artificial chromosome (PAC).
Endogenous alpha-synuclein: No
Corresponding human genotype: gene multiplication in familial PD; polymorphism in the non-coding region of the alpha-synuclein locus
Transgene insertion: 4 chromosomal insertions
References: Kuo 2010
Transgene expression
- 6 weeks-6 months: high (40x) and stable transgene expression is dectected in whole brain and distal colon.
Neurodegeneration
- 11 and 18 months: no evident loss of TH-positive neurons is detected in the SN
Dopamine Homeostasis
- 11 and 18 months: No deficits are observed
Inclusions
- 6-18 months: no alpha-synuclein abnormalities are observed in central and enteric nervous systems
Motor Behaviours
- No gross motor symptoms (ataxia, tremor, paralysis) are observed at any time
- 6-18 months: no impairments are detected in the rotarod and open field tests.
Response to L-DOPA treatment
- Not reported
Non motor Behaviours
- Colonic deficits: no deficits are observed at any time
- Whole-gut transit time: no deficits are observed at any time
- Olfaction: no deficits are observed at any time
- Autonomic dysfunctions: no deficits are observed at any time
Electrophysiology
- Not reported.
Neuroinflammation
- Not reported.