mDJ-1 KO/2 Mouse

General Information

Mouse: C57BL6/J

Mice in which exons 2 and 3 of the DJ-1 gene were deleted leading to the absence of DJ-1 protein in homozygous DJ-1^-/- mice. Male and female mice are fertile, show no changes in weight gain compared to wt mice, and comparable life span.

Endogenous DJ-1: No

Corresponding human genotype: Autosomal recessive genetic deletion in the DJ-1 gene causing a loss-of-function of the protein and leading to early-onset Parkinson’s disease (PARK7).

Mutated gene: DJ-1

References: Andres-Mateos 2007

Neurodegeneration

• 2-3 and 18-24 months: No apparent changes in the number TH-positive neurons

Dopamine Homeostasis

• 2-3 and 18-24 months: No apparent changes DA and DA metabolites levels are observed

Inclusions

• Not reported

Motor Behaviours

• 2-3 and 18-24 months: No changes spontaneous horizontal and vertical locomotion (open field test) are observed

Response to dopaminergic treatment

• Not reported.

Non motor Behaviours

• Not reported.

Electrophysiology

• Not reported.

Neuroinflammation

• Not reported

Updated 25/04/2018