Amsterdam dementia cohort

The ADC was setup in 2004 by including all patients who come to the Alzheimer Center for diagnostic work up and who consent to give all data, collected as part of the routine diagnostic work up, for research. The aim is and was to facilitate research into new and existing biomarkers in the broadest sense, to establish diagnostic, prognostic and theragnostic values and further insight into the pathogenesis of neurodegenerative dementias. The data are collected on a weekly basis and consist of baseline data and annual follow up data. Since it is conception it has grown into one of the largest clinical databases in the dementia field. More info on setup, characteristics and data collection can be found in van der Flier WM, Pijnenburg YA, Prins N, Lemstra AW, Bouwman FH, Teunissen CE, van Berckel BN, Stam CJ, Barkhof F, Visser PJ, van Egmond E, Scheltens P.

Optimizing patient care and research: the Amsterdam Dementia Cohort. J Alzheimers Dis. 2014;41(1):313-27. doi: 10.3233/JAD-132306. PubMed PMID: 24614907.

Last Update 21/09/2017

Types Neurodegenerative disease-specific cohort
Participant Types Condition diagnosed
Countries Netherlands
Genders Male and Female
Sample sizes 0 to 4,999
Ages 40 to 59
Brain related measures Behaviour|Cognitive function|Mental health|Neurological
Funtional rating Individual physiological|Individual psychological
Anthropometric Blood pressure|Height|Hip circumference|Waist circumference|Weight
Physical Cardiovascular|Hearing and Vision
Biological samples Blood|Cerebral spinal fluid (CSF)>CSF biomarker data available|Urine
Genotyping Gene screening
Brain imaging Electroencephalogram (EEG)|Magnetic resonance imaging (MRI)|Magnetoencephalography (MEG)|Positron emission tomography (PET) – amyloid|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking Consent for brain donation
Lifestyle Alcohol
Socio-economic Education|Marital status
Health service utilisation Formal health and social care service utilisation including private care
Institute names VU University Medical Center
Current Sample Sizes 0 to 4,999

age at recruitment >30
last updated
recruitment period 2004 – present
estimated current sample size number value >6000
cohort acronym ADC
start date 2004 – present
pi Professor Philip Scheltens
website http://www.alzheimercentrum.nl
contact details Alzheimer Center,
Department of Neurology,
VU University Medical Center,
Neuroscience Campus,
Amsterdam,
The Netherlands
abstract  ADC is a study aimed at facilitating research into new and existing biomarkers. It began in 2004 and continues to recruit participants under 30.
funders  Innovatie Fonds Ziektekostenverzekeraars, Stichting Diorapthe and Stichting VUmc fonds
contact email PI Email: [email protected]
contact phone number 31204440816
estimated current sample size 5,000 to 9,999
sample sizes 0