{"id":6302,"date":"2016-09-22T08:10:47","date_gmt":"2016-09-22T08:10:47","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=6302"},"modified":"2016-09-22T08:10:47","modified_gmt":"2016-09-22T08:10:47","slug":"new-model-recreates-early-spread-of-parkinsons-in-the-brain","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/ar\/2016\/09\/new-model-recreates-early-spread-of-parkinsons-in-the-brain\/","title":{"rendered":"New Model Recreates Early Spread of Parkinson\u2019s in the Brain"},"content":{"rendered":"

They\u2019re two of the biggest mysteries in Parkinson\u2019s disease research\u2013where does the disease start? And how can it be stopped early in the process?<\/p>\n

Now, a new laboratory model of Parkinson\u2019s is giving scientists an inside look at what happens in the brain years before motor symptoms appear. Specifically, it demonstrates how abnormal alpha-synuclein proteins, which are strongly associated with Parkinson\u2019s, gradually spread from an area of the brain implicated in the early stages of the disease to other regions of the brain ultimately damaged by the disease. The findings were published today in the Journal of Experimental Medicine<\/em>.<\/p>\n

Parkinson\u2019s is primarily a disease of aging, with most cases diagnosed after age 60. By the time symptoms appear, more than half of the brain cells that produce dopamine, a chemical messenger needed for voluntary movement, have died. What triggers this process is unknown, although evidence points to a combination of genetic, epigenetic and environmental factors. Strong evidence also suggests that clumps of abnormal alpha-synuclein play a role in the disease process. In recent years, scientists have found links to the early stages of Parkinson\u2019s in other areas of the body, namely the gut and the nose.<\/p>\n

The study demonstrates that alpha-synuclein travels along nerve cells in the olfactory bulb\u2013the part of the brain that controls sense of smell\u2013prior to the onset of motor symptoms and that this area may be particularly susceptible to the spread of alpha-synuclein, ultimately causing deficits in the sense of smell. Clumps of alpha-synuclein eventually reach several additional brain regions, including the brainstem area that houses dopamine cells.
\nPaper: “Widespread transneuronal propagation of \u03b1-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson\u2019s disease”<\/a>
\n<\/em>Reprinted from materials provided by the Van Andel Research Institute<\/a>.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

They\u2019re two of the biggest mysteries in Parkinson\u2019s disease research\u2013where […]<\/p>\nView Post<\/a>","protected":false},"author":3,"featured_media":4978,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-6302","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"\nNew Model Recreates Early Spread of Parkinson\u2019s in the Brain - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/es\/2016\/09\/new-model-recreates-early-spread-of-parkinsons-in-the-brain\/\" \/>\n<meta property=\"og:locale\" content=\"ar_AR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Model Recreates Early Spread of Parkinson\u2019s in the Brain - 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