Australian Imaging, Biomarker & Lifestyle Flagship Study on Ageing

AIBL is a study of over 2,000 people assessed over a long period of time (over 10 years) to determine which biomarkers, cognitive characteristics, and health and lifestyle factors determine subsequent development of symptomatic Alzheimer’s Disease (AD).

The baseline inception cohort consisted of:
i. 211 individuals with AD as defined by NINCDS-ADRDA (McKhann et al, 1984);
ii. 133 individuals with Mild Cognitive Impairment (MCI)
iii. 768 healthy individuals without cognitive impairment. This group included volunteers with at least one copy of the ApoE ?4 allele, volunteers without a copy of the ApoE ?4 allele and 396 volunteers who expressed subjective concern about their memory function.

The enrichment cohort consists of:
i. 142 individuals with AD
ii. 220 individuals with MCI
iii. 582 individuals with without cognitive impairment.

The data was collected through clinics and questionnaires.

Last Update 21/09/2017

Types Neurodegenerative disease-specific cohort
Participant Types Condition diagnosed
Countries Australia
Genders Male and Female
Sample sizes 0 to 4,999
Ages 60 to 100
Brain related measures Behaviour|Cognitive function|Mental health|Neurological
Funtional rating
Anthropometric Blood pressure|Height|Waist circumference|Weight
Physical
Biological samples Blood|Cerebral spinal fluid (CSF)>CSF biomarker data available|Microbiome|Other|Saliva|Urine
Genotyping Gene screening
Brain imaging Magnetic resonance imaging (MRI)|Positron emission tomography (PET) – amyloid
Brain banking
Lifestyle Alcohol|Smoking
Socio-economic Education|Marital status
Health service utilisation Formal health and social care service utilisation including private care
Institute names Florey Institute of Neuroscience and Mental Health, Austin Health, Edith Cowan University and CSIRO
Current Sample Sizes 0 to 4,999

age at recruitment >60
last updated
recruitment period 2006-2008| 2010
estimated current sample size number value 2100
cohort acronym AIBL
start date 2006-2008| 2010
pi Professor David Ames
website https://aibl.csiro.au/about/
contact details Data Access
https://aibl.csiro.au/research/support/
abstract  AIBL is an ND specific cohort aimed at identifying biomarkers, cognitive characteristics, and health and lifestyle factors associated with the development of AD. It began in 2006 recruiting 2,500 participants over 60.
funders  Science and Industry Endowment Fund
contact email Email: [email protected]
contact phone number 
estimated current sample size 0 to 4,999
sample sizes 2500