{"id":7254,"date":"2017-03-27T08:36:35","date_gmt":"2017-03-27T08:36:35","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=7254"},"modified":"2022-10-20T19:29:53","modified_gmt":"2022-10-20T19:29:53","slug":"parkinsons-disease-linked-to-gut-microbiome","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/bg\/2017\/03\/parkinsons-disease-linked-to-gut-microbiome\/","title":{"rendered":"Parkinson\u2019s Disease Linked to Gut Microbiome"},"content":{"rendered":"<p>Scientists have discovered for the first time a functional link between bacteria in the intestines and Parkinson\u2019s disease (PD). The researchers show that changes in the composition of gut bacterial populations\u2013or possibly gut bacteria themselves\u2013are actively contributing to and may even cause the deterioration of motor skills that is the hallmark of this disease.<\/p>\n<p>The work\u2013which has profound implications for the treatment of PD\u2013appears in <em>Cell<\/em>.<\/p>\n<p>PD affects up to 10 million worldwide, making it the second most common neurodegenerative disease. Characteristic features of PD include symptoms such as tremors and difficulty walking, aggregation of a protein called alpha-synuclein (\u03b1Syn) within cells in the brain and gut, and the presence of inflammatory molecules called cytokines within the brain. In addition, 75 percent of people with PD have gastrointestinal (GI) abnormalities, primarily constipation.<\/p>\n<p>To test if bacteria in the gut may contribute to PD, the researchers utilized mice that overproduce \u03b1Syn and display symptoms of Parkinson\u2019s. One group of mice had a complex consortium of gut bacteria; the others, called germ-free mice, were bred in a completely sterile environment and thus lacked gut bacteria. The researchers had both groups of mice perform several tasks to measure their motor skills, such as running on treadmills, crossing a beam, and descending from a pole. The germ-free mice performed significantly better than the mice with a complete microbiome.<\/p>\n<p>When gut bacteria break down dietary fiber, they produce molecules called short-chain fatty acids (SCFAs), such as acetate and butyrate. Previous research has shown that these molecules also can activate immune responses in the brain. Thus, the researchers hypothesized that an imbalance in the levels of SCFAs regulates brain inflammation and other symptoms of PD. Indeed, when germ-free mice were fed SCFAs, cells called microglia\u2013which are immune cells residing in the brain\u2013became activated. Such inflammatory processes can cause neurons to malfunction or even die. In fact, germ-free mice fed SCFAs now showed motor disabilities and \u03b1Syn aggregation in regions of the brain linked to PD.<\/p>\n<p>In a final set of experiments, the researchers obtained fecal samples from patients with PD and from healthy controls. The human microbiome samples were transplanted into germ-free mice, which then remarkably began to exhibit symptoms of PD. These mice also showed higher levels of SCFAs in their feces. Transplanted fecal samples from healthy individuals, in contrast, did not trigger PD symptoms, unlike mice harboring gut bacteria from PD patients.<\/p>\n<p><strong>Paper: <a href=\"http:\/\/www.cell.com\/cell\/abstract\/S0092-8674(16)31590-2\">\u201cGut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson\u2019s Disease\u201d<\/a><\/strong><br \/>\n<strong> Reprinted from materials provided by <a href=\"https:\/\/www.caltech.edu\/news\/parkinsons-disease-linked-microbiome-53109\">CalTech<\/a>.<\/strong><\/p>\n<div style=\"position: absolute; opacity: 0; visibility: hidden;\">\n<h2>Real money online pokies<\/h2>\n<p>Wish to play pokie games for real money? Prior to that, check out this review written by our friends at <a href=\"https:\/\/exycasinos.com\/online-pokies\/real-money-pokies\/\">Exycasinos.com<\/a>. 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Moreover, gamblers are to find out if it&#8217;s better to play real money pokies or for free.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Scientists have discovered for the first time a functional link [&hellip;]<\/p>\n<a href=\"https:\/\/neurodegenerationresearch.eu\/bg\/2017\/03\/parkinsons-disease-linked-to-gut-microbiome\/\">View Post<\/a>","protected":false},"author":3,"featured_media":4978,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-7254","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Parkinson\u2019s Disease Linked to Gut Microbiome - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/2017\/03\/parkinsons-disease-linked-to-gut-microbiome\/\" \/>\n<meta property=\"og:locale\" content=\"bg_BG\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Parkinson\u2019s Disease Linked to Gut Microbiome - 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