BIOTERIO – Centre for Neuroscience and Cell Biology, FMUC

Name of resource
BIOTERIO – Centre for Neuroscience and Cell Biology, FMUC
Name of Principal Investigator

Title Dr/Dr
First name
Last name Pereira/Rego

Address of institution where award is held

Institution Center for Neuroscience and Cell Biology (CNC) – Univ Coimbra
Street Address R. Larga, 6
City Coimbra
Postcode 3004-517

Country

  • Portugal

    • Website
    http://www.cnbc.pt/
    Contact email
    [email protected]
    Summary

    1a. The resource holds animal models relevant to the study of the following neurodegenerative diseases

  • Alzheimer’s disease and other dementias
  • Huntington’s disease

    • 1b. The resource holds:

  • Animals

    • 2a. The resource acts as a centre for access and distribution to external groups (who are not the PIs of the resource)

    2b. Procedures and rules for access

  • Apply to PI or co-ordinator at resource
  • Access through collaboration with PI only
  • Applicant needs to provide separate external ethics approval
  • Other requirements exist
  • National access
  • International access
  • Other requirements exist

    • 3a. Does the resource develop animal models for external groups
    1
    3b. Types of models provided

  • Not applicable

    • 4a This activity is supported as:

  • Not applicable

    • 4b. The supplied material deposited in a central repository
    1
    5a Disease models available

    Disease Species Available to external user (Y/N) Full phenotypic character (Y/N or partial) Phenotypes Genotypes or other subtypes
    AD N Y Cognitive deficits, senile plaques, neurofibrillary tangles, synaptic loss in cerebral cortex and hippocampus 3xTg-AD (human mutant APP, PS1, tau)- background C57BL x 129sv Mouse
    YAC mouse model of HD expressing full-length human mutant huntingtin with 128 glutamines (YAC128, lines HD55 and HD53) HD Mouse Y Y Hyperkinetic phenotype first manifested, followed by progressive motor deficits and age-dependent striatal neurodegeneration

    7a. Maintenance of the resource is dependent on continued funding
    2
    7b. End date of current funding period
    2013
    7c. Expected lifespan of the resource (in years)
    10
    7d. Other plans affecting future use
    In one year more space available for production of new mice models colonies.

    In three years probably a new facility.

    BIOTERIO – Centre for Neuroscience and Cell Biology, FMUC

    Experimental Models
    Portugal
    Alzheimer’s disease & other dementias|Huntington’s disease
    2011

     

     

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