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The rpAD study is a longitudinal study, which recruits patients from the entire federal territory. In addition, patients from the Clinical Dementia Centre are recruited at the Neurological and Psychiatric Clinic of the University Medical Center of G’ttingen, with these usually classical clinical forms being internal controls. The aim of the study is to characterize the biological factors and parameters that define the disease progression in AD.
After the patient is informed and consent is given, the inclusion examination is carried out. It includes a detailed history and anamnesis as well as a physical examination, which includes an in-depth examination of the neurological status. A neuropsychological test for cognitive testing is performed using the CERAD-plus test battery. Furthermore, the GDS score is obtained, which allows an assessment of the severity of the cognitive deficits by means of a 7-stage classification. The ADL score is used to assess the activities of daily life (Lawton and Brody 1969).
Six months after the initial examination, a telephone follow-up is carried out. Further investigations are carried out on an annual basis and correspond to the initial examination.
Last Update 21/09/2017
Types Neurodegenerative disease-specific cohort
Participant Types Condition diagnosed
Countries Germany
Genders Male and Female
Sample sizes
Ages 60 to 100
Brain related measures Cognitive function|Mental health|Neurological
Funtional rating Individual physiological|Individual psychological
Anthropometric Blood pressure|Height|Weight
Physical Cardiovascular
Biological samples Blood|Cerebral spinal fluid (CSF)>CSF biomarker data available
Genotyping Gene screening
Brain imaging Electroencephalogram (EEG)|Magnetic resonance imaging (MRI)|Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking Consent for brain donation
Lifestyle Alcohol|Dietary habits|Physical activity|Smoking
Socio-economic Education|Ethnic group|Family circumstances|Housing and accommodation|Informal support|Marital status|Occupation and employment|Unpaid care
Health service utilisation
Institute names University Medical School, Department of Neurology, G’ttingen
Current Sample Sizes
age at recruitment 70
last updated
recruitment period 2008 – Present
estimated current sample size number value 300
cohort acronym rpAD Study
start date 2008 – Present
pi Professor Inga Zerr
website http://www.knd-demenzen.de/die-verbuende/verbund-rpad/projektbeschreibung.html
contact details University Medical School
Department of Neurology
Robert Kochstrasse
40 37075
G’ttingen
abstract The rpAD study is a longitudinal study which aims to characterise the biological factors and parameters that define the disease progression in AD. The study began in 2008 and is still recruiting.
funders Kompetenznetz Degenerative Demenzen -KNDD by BMBF
contact email E-mail: [email protected]
contact phone number Phone: +49 (0) 551/39 66 36
estimated current sample size 0 to 4,999
sample sizes