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Cohort Acronym
Cohort typeGeneral population-based cohort
Disease
Dementia (unclassified), Parkinson's disease, Subjective memory complaints (SMC) or subjective cognitive decline (SCD)
Participant type
No diagnosis
Profile
Recruitment Period
2016 - Present
Sample size at start or planned sample size if still recruiting
30000
Estimated Current Sample Size
10,000 to 19,999
Age at Recruitment
>30
Gender
Male and Female
Abstract
The Rhineland Study is a prospective cohort study, which began in March 2016. It will include up to 30,000 participants from Bonn and asses their physical and mental health over their lifespan. The study is scheduled to run for decades and participants will be re-examined every 3-4 years.
As neurodegenerative diseases and their pathologies develop over a long time before first symptoms start to show, the Rhineland Study will include men and women aged 30 years and above regardless of their health status.
The main aims of the study are:
1. To investigate modifiable and non-modifiable causes of neurodegenerative and neuropsychiatric diseases
2. To find biomarkers/(multimodal) biomarker profiles to identify individuals at risk for neurodegenerative or neuropsychiatric disease, who might benefit from preventive interventions
3. To investigate (patho)physiology over the adult life course, with specific emphasis on brain-related outcomes.
Last Update 21/09/2017
Country
Germany
Contact details
Institution name
The German Center for Neurodegenerative Diseases (DZNE)
Principal Investiator (PI)
Prof. Dr. Monique M. B. Breteler
Contact phone number
Tel: +49 (0) 228 / 43302-929
Address
German Center for Neurodegenerative Diseases (DZNE)
Sigmund-Freud-Str. 27
53127 Bonn
Funders (Core support)
Long term institutional core funding
Variables Collected
Brain related measures: Behaviour, Cognitive function, Mental health, Neurological
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision, Reproductive
Biological samples: Blood, Microbiome, Other, Urine
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Informal support, Marital status, Occupation and employment, Unpaid care
Health service utilisation: N/A
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