{"id":6481,"date":"2016-11-09T12:19:05","date_gmt":"2016-11-09T12:19:05","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=6481"},"modified":"2016-11-09T12:19:05","modified_gmt":"2016-11-09T12:19:05","slug":"common-molecular-mechanism-of-parkinsons-pathology-discovered","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/da\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/","title":{"rendered":"Common molecular mechanism of Parkinson\u2019s pathology discovered"},"content":{"rendered":"<p>Researchers have located an intracellular defect that they believe is probably common to all forms of Parkinson\u2019s disease. This defect, which precedes the death of a group of nerve cells whose loss is the hallmark of the condition, plays a critical role in triggering that die-off.<\/h1>\n<p>Described in a study published in <em>Cell Stem Cell<\/em>, the defect renders cells unable to quickly dismantle their mitochondria when they wear out, stop supplying energy and start spewing out pollutants instead.<\/p>\n<p>The most frequent genetic mutations responsible for familial Parkinson\u2019s occur at various points along a gene coding for a protein called LRRK2. Until now, no one could clearly account for LRRK2\u2019s connection to Parkinson\u2019s.<\/p>\n<p>The researchers showed that before faulty mitochondria can be decommissioned, they must first be detached from the cytoskeleton, a network of molecular filaments and tubules that spans and shapes most of our cells. Only after the mitochondria are detached can the cell destroy them. But this can\u2019t happen, the team found, until a protein called Miro that anchors mitochondria to the cytoskeleton is severed.<\/p>\n<p>The researchers discovered that Miro\u2019s removal can occur only after LRRK2 forms a complex with Miro. Defective LRRK2 is impaired in forming this complex, resulting in significant delays in Miro\u2019s removal.<\/p>\n<p>When the researchers biochemically induced excessive free-radical production in the nerve cells, those from every Parkinson\u2019s patient sampled \u2014 familial and sporadic alike \u2014 died in much greater numbers than equivalent cells derived from healthy patients.<\/p>\n<p>The scientists discovered they could prevent the delay in Parkinson\u2019s-derived nerve cells\u2019 dismantling of faulty mitochondria, as well as forestall those cells\u2019 untimely death in the face of free-radical onslaught. They performed a biochemical trick that reduced Miro levels in the cells. The reduction wasn\u2019t enough to dislodge healthy mitochondria from the cytoskeleton, but it reduced their attachment intensities closer to the point at which detachment could occur. When the scientists then chemically induced mitochondrial damage, no increased mitochondrial drop-off or degradation took place in the nerve cells derived from healthy subjects. But in the equivalent LRRK2G2019S nerve cells, the previously seen delays pretty much disappeared \u2014 and far fewer of these cells died. Lowering Miro concentrations, in those cells, compensated for their Miro-chopping impairment.<\/p>\n<p>This discovery could lead to not only more accurate but much earlier diagnoses of Parkinson\u2019s disease and could also point to entirely new pharmacological approaches to treating it, the researchers said.<\/p>\n<p>Paper: <a href=\"http:\/\/www.cell.com\/cell-stem-cell\/abstract\/S1934-5909(16)30249-1\">\u201cFunctional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson\u2019s Disease\u201d<\/a><br \/>\nReprinted from materials provided by the <a href=\"https:\/\/med.stanford.edu\/news\/all-news\/2016\/09\/common-molecular-mechanism-of-parkinsons-pathology-discovered.html\">Stanford University Medical Center<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have located an intracellular defect that they believe is [&hellip;]<\/p>\n<a href=\"https:\/\/neurodegenerationresearch.eu\/da\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/\">View Post<\/a>","protected":false},"author":3,"featured_media":4978,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-6481","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Common molecular mechanism of Parkinson\u2019s pathology discovered - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/\" \/>\n<meta property=\"og:locale\" content=\"da_DK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Common molecular mechanism of Parkinson\u2019s pathology discovered - JPND Neurodegenerative Disease Research\" \/>\n<meta property=\"og:description\" content=\"Researchers have located an intracellular defect that they believe is [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/\" \/>\n<meta property=\"og:site_name\" content=\"JPND Neurodegenerative Disease Research\" \/>\n<meta property=\"article:published_time\" content=\"2016-11-09T12:19:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2015\/05\/Parkinsons.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1754\" \/>\n\t<meta property=\"og:image:height\" content=\"1240\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"jpnd\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@JPNDeurope\" \/>\n<meta name=\"twitter:site\" content=\"@JPNDeurope\" \/>\n<meta name=\"twitter:label1\" content=\"Skrevet af\" \/>\n\t<meta name=\"twitter:data1\" content=\"jpnd\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimeret l\u00e6setid\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutter\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/\"},\"author\":{\"name\":\"jpnd\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#\\\/schema\\\/person\\\/a97e49cae588ead81db59e48a4e63c2a\"},\"headline\":\"Common molecular mechanism of Parkinson\u2019s pathology discovered\",\"datePublished\":\"2016-11-09T12:19:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/\"},\"wordCount\":446,\"publisher\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2015\\\/05\\\/Parkinsons.jpg\",\"articleSection\":[\"Research News (General)\"],\"inLanguage\":\"da-DK\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/\",\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/\",\"name\":\"Common molecular mechanism of Parkinson\u2019s pathology discovered - JPND Neurodegenerative Disease Research\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2015\\\/05\\\/Parkinsons.jpg\",\"datePublished\":\"2016-11-09T12:19:05+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/#breadcrumb\"},\"inLanguage\":\"da-DK\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"da-DK\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/#primaryimage\",\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2015\\\/05\\\/Parkinsons.jpg\",\"contentUrl\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2015\\\/05\\\/Parkinsons.jpg\",\"width\":1754,\"height\":1240},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2016\\\/11\\\/common-molecular-mechanism-of-parkinsons-pathology-discovered\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Common molecular mechanism of Parkinson\u2019s pathology discovered\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#website\",\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/\",\"name\":\"JPND Neurodegenerative Disease Research\",\"description\":\"Neurodegenerative Disease Research\",\"publisher\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"da-DK\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#organization\",\"name\":\"JPND\",\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"da-DK\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2022\\\/03\\\/logo.png\",\"contentUrl\":\"https:\\\/\\\/www.neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2022\\\/03\\\/logo.png\",\"width\":248,\"height\":129,\"caption\":\"JPND\"},\"image\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/x.com\\\/JPNDeurope\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#\\\/schema\\\/person\\\/a97e49cae588ead81db59e48a4e63c2a\",\"name\":\"jpnd\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"da-DK\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g\",\"caption\":\"jpnd\"},\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/da\\\/author\\\/jpnd\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Common molecular mechanism of Parkinson\u2019s pathology discovered - JPND Neurodegenerative Disease Research","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/","og_locale":"da_DK","og_type":"article","og_title":"Common molecular mechanism of Parkinson\u2019s pathology discovered - JPND Neurodegenerative Disease Research","og_description":"Researchers have located an intracellular defect that they believe is [&hellip;]","og_url":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/","og_site_name":"JPND Neurodegenerative Disease Research","article_published_time":"2016-11-09T12:19:05+00:00","og_image":[{"width":1754,"height":1240,"url":"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2015\/05\/Parkinsons.jpg","type":"image\/jpeg"}],"author":"jpnd","twitter_card":"summary_large_image","twitter_creator":"@JPNDeurope","twitter_site":"@JPNDeurope","twitter_misc":{"Skrevet af":"jpnd","Estimeret l\u00e6setid":"2 minutter"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/#article","isPartOf":{"@id":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/"},"author":{"name":"jpnd","@id":"https:\/\/neurodegenerationresearch.eu\/#\/schema\/person\/a97e49cae588ead81db59e48a4e63c2a"},"headline":"Common molecular mechanism of Parkinson\u2019s pathology discovered","datePublished":"2016-11-09T12:19:05+00:00","mainEntityOfPage":{"@id":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/"},"wordCount":446,"publisher":{"@id":"https:\/\/neurodegenerationresearch.eu\/#organization"},"image":{"@id":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/#primaryimage"},"thumbnailUrl":"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2015\/05\/Parkinsons.jpg","articleSection":["Research News (General)"],"inLanguage":"da-DK"},{"@type":"WebPage","@id":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/","url":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/","name":"Common molecular mechanism of Parkinson\u2019s pathology discovered - JPND Neurodegenerative Disease Research","isPartOf":{"@id":"https:\/\/neurodegenerationresearch.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/#primaryimage"},"image":{"@id":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/#primaryimage"},"thumbnailUrl":"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2015\/05\/Parkinsons.jpg","datePublished":"2016-11-09T12:19:05+00:00","breadcrumb":{"@id":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/#breadcrumb"},"inLanguage":"da-DK","potentialAction":[{"@type":"ReadAction","target":["https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/"]}]},{"@type":"ImageObject","inLanguage":"da-DK","@id":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/#primaryimage","url":"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2015\/05\/Parkinsons.jpg","contentUrl":"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2015\/05\/Parkinsons.jpg","width":1754,"height":1240},{"@type":"BreadcrumbList","@id":"https:\/\/neurodegenerationresearch.eu\/2016\/11\/common-molecular-mechanism-of-parkinsons-pathology-discovered\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/neurodegenerationresearch.eu\/"},{"@type":"ListItem","position":2,"name":"Common molecular mechanism of Parkinson\u2019s pathology discovered"}]},{"@type":"WebSite","@id":"https:\/\/neurodegenerationresearch.eu\/#website","url":"https:\/\/neurodegenerationresearch.eu\/","name":"JPND Neurodegenerative Disease Research","description":"Neurodegenerative Disease Research","publisher":{"@id":"https:\/\/neurodegenerationresearch.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/neurodegenerationresearch.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"da-DK"},{"@type":"Organization","@id":"https:\/\/neurodegenerationresearch.eu\/#organization","name":"JPND","url":"https:\/\/neurodegenerationresearch.eu\/","logo":{"@type":"ImageObject","inLanguage":"da-DK","@id":"https:\/\/neurodegenerationresearch.eu\/#\/schema\/logo\/image\/","url":"https:\/\/www.neurodegenerationresearch.eu\/wp-content\/uploads\/2022\/03\/logo.png","contentUrl":"https:\/\/www.neurodegenerationresearch.eu\/wp-content\/uploads\/2022\/03\/logo.png","width":248,"height":129,"caption":"JPND"},"image":{"@id":"https:\/\/neurodegenerationresearch.eu\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/JPNDeurope"]},{"@type":"Person","@id":"https:\/\/neurodegenerationresearch.eu\/#\/schema\/person\/a97e49cae588ead81db59e48a4e63c2a","name":"jpnd","image":{"@type":"ImageObject","inLanguage":"da-DK","@id":"https:\/\/secure.gravatar.com\/avatar\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g","caption":"jpnd"},"url":"https:\/\/neurodegenerationresearch.eu\/da\/author\/jpnd\/"}]}},"_links":{"self":[{"href":"https:\/\/neurodegenerationresearch.eu\/da\/wp-json\/wp\/v2\/posts\/6481","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neurodegenerationresearch.eu\/da\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neurodegenerationresearch.eu\/da\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neurodegenerationresearch.eu\/da\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/neurodegenerationresearch.eu\/da\/wp-json\/wp\/v2\/comments?post=6481"}],"version-history":[{"count":0,"href":"https:\/\/neurodegenerationresearch.eu\/da\/wp-json\/wp\/v2\/posts\/6481\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neurodegenerationresearch.eu\/da\/wp-json\/wp\/v2\/media\/4978"}],"wp:attachment":[{"href":"https:\/\/neurodegenerationresearch.eu\/da\/wp-json\/wp\/v2\/media?parent=6481"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neurodegenerationresearch.eu\/da\/wp-json\/wp\/v2\/categories?post=6481"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neurodegenerationresearch.eu\/da\/wp-json\/wp\/v2\/tags?post=6481"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}