Determining Factors and The Progression of The Onset of Alzheimer’s Disease and Cognitive Impairment

MEMENTO
Determining Factors and The Progression of The Onset of Alzheimer’s Disease and Cognitive Impairment

[email protected] | [email protected]
Alzheimer’s Foundation Plan (Fondation Plan Alzheimer), PHRC, GE Healthcare, AVID
Alzheimer’s Foundation Plan (Fondation Plan Alzheimer), PHRC, GE Healthcare, AVID

Data collection ongoing| Data analysis ongoing

French

France

Secondary samples: plasma| Secondary samples: DNA| Secondary samples: RNA

Yes, for all the cohort

Demographics, neuropsychometric test, neuroimaging, blood and CSF biomarkers, DNA

Yes
Dementia

Yes – intend to apply for funding

Alzheimer’s disease and other dementias

Data is held as individual records
Data is web-based
Data held on computer based records
No
Yes
Apply to PI or co-ordinator at resource| Access independent of collaboration with PI| Access committee mechanism| Access committee mechanism| International access| Access to industry| Access for pilot studies permitted| Resource has own ethics approval so usually no need for separate external ethics approval| Data are not distributed, access through our secured system
No requirement to make data publicly available
Yes

Yes
Identification and validation of biomarkers or combination of biomarkers that best predict the occurrence of dementia
The largest naturalistic cohort on brain health, with a rigorous prospective design, extensive follow-up (at least 5 years), standardized procedures, multiple biomarkers (imaging, blood CSF) assessed with standardized acquisitions and analyses
0
B Dubois, APHP, The Insight Cohort| B Dubois, APHP, The Insight Cohort

1,000-5,000 participants
No
Prospective cohort|Longitudinal

Yes
by definition controls are those who do not get the disease at a give,n time of analysis
01/01/2011
01/01/2019
Data collection ongoing| Data analysis ongoing
Only through the study

Data summarised in database

Database is web-based
No
No
Determining Factors and The Progression of The Onset of Alzheimer’s Disease and Cognitive Impairment
2016-2020

Population Cohorts
France
Alzheimer’s disease & other dementias
2016