{"id":6801,"date":"2017-01-23T08:54:07","date_gmt":"2017-01-23T08:54:07","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=6801"},"modified":"2017-01-23T08:54:07","modified_gmt":"2017-01-23T08:54:07","slug":"study-reveals-role-of-rna-binding-proteins-in-als","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/el\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/","title":{"rendered":"Study Reveals Role of RNA-Binding Proteins in ALS"},"content":{"rendered":"<p>Although only 10 percent of amyotrophic lateral sclerosis (ALS) cases are hereditary, a significant number of them are caused by mutations that affect proteins that bind RNA, a type of genetic material.<\/p>\n<p>Researchers studied several ALS cases with a mutation in a RNA-binding protein known as hnRNP A2\/B1. In a study published in <em>Neuron<\/em>, they describe how damage to this protein contributes to ALS by scrambling crucial cellular messaging systems.<\/p>\n<p>To unravel the role RNA-binding proteins play in ALS, the research team gathered skin cells from four patients with the disease \u2014 three with mutations in the hnRNP A2\/B1 gene, one with a mutation in a different gene \u2014 and two healthy volunteers as controls. The researchers coaxed these skin cells into becoming a special kind of stem cell called induced pluripotent stem cells (iPSCs) and ultimately turned these patient-specific stem cells into motor neurons. This technique provided them with personalized models of each patient\u2019s disease, in a laboratory dish.<\/p>\n<p>To determine the effects of the mutant hnRNP A2\/B1 proteins in these samples, the researchers then measured the activity of thousands of genes in each of the ALS and healthy motor neuron samples. In the ALS patient samples, the team found that the hnRNP A2\/B1 mutation these patients had didn\u2019t merely disable the protein. Instead, the mutation gave the protein new toxic properties that scrambled RNA processing, and ultimately led to the death of motor neurons.<\/p>\n<p><strong>Paper: <a href=\"http:\/\/www.cell.com\/neuron\/abstract\/S0896-6273(16)30655-9?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627316306559%3Fshowall%3Dtrue\">\u201cProtein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System\u201d<\/a><\/strong><br \/>\n<strong>Reprinted from materials provided by <a href=\"http:\/\/ucsdnews.ucsd.edu\/pressrelease\/als_study_reveals_role_of_rna_binding_proteins\">UCSD<\/a>.<\/strong><\/p>\n<p><em>\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Although only 10 percent of amyotrophic lateral sclerosis (ALS) cases [&hellip;]<\/p>\n<a href=\"https:\/\/neurodegenerationresearch.eu\/el\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/\">View Post<\/a>","protected":false},"author":3,"featured_media":2871,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-6801","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Study Reveals Role of RNA-Binding Proteins in ALS - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study Reveals Role of RNA-Binding Proteins in ALS - JPND Neurodegenerative Disease Research\" \/>\n<meta property=\"og:description\" content=\"Although only 10 percent of amyotrophic lateral sclerosis (ALS) cases [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/\" \/>\n<meta property=\"og:site_name\" content=\"JPND Neurodegenerative Disease Research\" \/>\n<meta property=\"article:published_time\" content=\"2017-01-23T08:54:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2014\/09\/HiRes-e1410939675579.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"626\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"jpnd\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@JPNDeurope\" \/>\n<meta name=\"twitter:site\" content=\"@JPNDeurope\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"jpnd\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/\"},\"author\":{\"name\":\"jpnd\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#\\\/schema\\\/person\\\/a97e49cae588ead81db59e48a4e63c2a\"},\"headline\":\"Study Reveals Role of RNA-Binding Proteins in ALS\",\"datePublished\":\"2017-01-23T08:54:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/\"},\"wordCount\":268,\"publisher\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2014\\\/09\\\/HiRes-e1410939675579.jpg\",\"articleSection\":[\"Research News (General)\"],\"inLanguage\":\"el\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/\",\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/\",\"name\":\"Study Reveals Role of RNA-Binding Proteins in ALS - JPND Neurodegenerative Disease Research\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2014\\\/09\\\/HiRes-e1410939675579.jpg\",\"datePublished\":\"2017-01-23T08:54:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/#breadcrumb\"},\"inLanguage\":\"el\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"el\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/#primaryimage\",\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2014\\\/09\\\/HiRes-e1410939675579.jpg\",\"contentUrl\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2014\\\/09\\\/HiRes-e1410939675579.jpg\",\"width\":800,\"height\":626},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/01\\\/study-reveals-role-of-rna-binding-proteins-in-als\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study Reveals Role of RNA-Binding Proteins in ALS\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#website\",\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/\",\"name\":\"JPND Neurodegenerative Disease Research\",\"description\":\"Neurodegenerative Disease Research\",\"publisher\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"el\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#organization\",\"name\":\"JPND\",\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"el\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2022\\\/03\\\/logo.png\",\"contentUrl\":\"https:\\\/\\\/www.neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2022\\\/03\\\/logo.png\",\"width\":248,\"height\":129,\"caption\":\"JPND\"},\"image\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/x.com\\\/JPNDeurope\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#\\\/schema\\\/person\\\/a97e49cae588ead81db59e48a4e63c2a\",\"name\":\"jpnd\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"el\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g\",\"caption\":\"jpnd\"},\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/el\\\/author\\\/jpnd\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Study Reveals Role of RNA-Binding Proteins in ALS - JPND Neurodegenerative Disease Research","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/","og_locale":"el_GR","og_type":"article","og_title":"Study Reveals Role of RNA-Binding Proteins in ALS - JPND Neurodegenerative Disease Research","og_description":"Although only 10 percent of amyotrophic lateral sclerosis (ALS) cases [&hellip;]","og_url":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/","og_site_name":"JPND Neurodegenerative Disease Research","article_published_time":"2017-01-23T08:54:07+00:00","og_image":[{"width":800,"height":626,"url":"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2014\/09\/HiRes-e1410939675579.jpg","type":"image\/jpeg"}],"author":"jpnd","twitter_card":"summary_large_image","twitter_creator":"@JPNDeurope","twitter_site":"@JPNDeurope","twitter_misc":{"Written by":"jpnd","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/#article","isPartOf":{"@id":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/"},"author":{"name":"jpnd","@id":"https:\/\/neurodegenerationresearch.eu\/#\/schema\/person\/a97e49cae588ead81db59e48a4e63c2a"},"headline":"Study Reveals Role of RNA-Binding Proteins in ALS","datePublished":"2017-01-23T08:54:07+00:00","mainEntityOfPage":{"@id":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/"},"wordCount":268,"publisher":{"@id":"https:\/\/neurodegenerationresearch.eu\/#organization"},"image":{"@id":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/#primaryimage"},"thumbnailUrl":"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2014\/09\/HiRes-e1410939675579.jpg","articleSection":["Research News (General)"],"inLanguage":"el"},{"@type":"WebPage","@id":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/","url":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/","name":"Study Reveals Role of RNA-Binding Proteins in ALS - JPND Neurodegenerative Disease Research","isPartOf":{"@id":"https:\/\/neurodegenerationresearch.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/#primaryimage"},"image":{"@id":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/#primaryimage"},"thumbnailUrl":"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2014\/09\/HiRes-e1410939675579.jpg","datePublished":"2017-01-23T08:54:07+00:00","breadcrumb":{"@id":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/#breadcrumb"},"inLanguage":"el","potentialAction":[{"@type":"ReadAction","target":["https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/"]}]},{"@type":"ImageObject","inLanguage":"el","@id":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/#primaryimage","url":"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2014\/09\/HiRes-e1410939675579.jpg","contentUrl":"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2014\/09\/HiRes-e1410939675579.jpg","width":800,"height":626},{"@type":"BreadcrumbList","@id":"https:\/\/neurodegenerationresearch.eu\/2017\/01\/study-reveals-role-of-rna-binding-proteins-in-als\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/neurodegenerationresearch.eu\/"},{"@type":"ListItem","position":2,"name":"Study Reveals Role of RNA-Binding Proteins in ALS"}]},{"@type":"WebSite","@id":"https:\/\/neurodegenerationresearch.eu\/#website","url":"https:\/\/neurodegenerationresearch.eu\/","name":"JPND Neurodegenerative Disease Research","description":"Neurodegenerative Disease Research","publisher":{"@id":"https:\/\/neurodegenerationresearch.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/neurodegenerationresearch.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"el"},{"@type":"Organization","@id":"https:\/\/neurodegenerationresearch.eu\/#organization","name":"JPND","url":"https:\/\/neurodegenerationresearch.eu\/","logo":{"@type":"ImageObject","inLanguage":"el","@id":"https:\/\/neurodegenerationresearch.eu\/#\/schema\/logo\/image\/","url":"https:\/\/www.neurodegenerationresearch.eu\/wp-content\/uploads\/2022\/03\/logo.png","contentUrl":"https:\/\/www.neurodegenerationresearch.eu\/wp-content\/uploads\/2022\/03\/logo.png","width":248,"height":129,"caption":"JPND"},"image":{"@id":"https:\/\/neurodegenerationresearch.eu\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/JPNDeurope"]},{"@type":"Person","@id":"https:\/\/neurodegenerationresearch.eu\/#\/schema\/person\/a97e49cae588ead81db59e48a4e63c2a","name":"jpnd","image":{"@type":"ImageObject","inLanguage":"el","@id":"https:\/\/secure.gravatar.com\/avatar\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/b3244fc6099279fad29cb751cb709c5ee57befcda19ef0b44a4f0067989d7f7e?s=96&d=mm&r=g","caption":"jpnd"},"url":"https:\/\/neurodegenerationresearch.eu\/el\/author\/jpnd\/"}]}},"_links":{"self":[{"href":"https:\/\/neurodegenerationresearch.eu\/el\/wp-json\/wp\/v2\/posts\/6801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neurodegenerationresearch.eu\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neurodegenerationresearch.eu\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neurodegenerationresearch.eu\/el\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/neurodegenerationresearch.eu\/el\/wp-json\/wp\/v2\/comments?post=6801"}],"version-history":[{"count":0,"href":"https:\/\/neurodegenerationresearch.eu\/el\/wp-json\/wp\/v2\/posts\/6801\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/neurodegenerationresearch.eu\/el\/wp-json\/wp\/v2\/media\/2871"}],"wp:attachment":[{"href":"https:\/\/neurodegenerationresearch.eu\/el\/wp-json\/wp\/v2\/media?parent=6801"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neurodegenerationresearch.eu\/el\/wp-json\/wp\/v2\/categories?post=6801"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neurodegenerationresearch.eu\/el\/wp-json\/wp\/v2\/tags?post=6801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}