Cohort Acronym
LCC
Cohort type
Neurodegenerative disease-specific cohort
Disease
Parkinson's disease
Participant type
At-risk diagnosis, Condition diagnosed, No diagnosis
Profile
LCC
Cohort type
Neurodegenerative disease-specific cohort
Disease
Parkinson's disease
Participant type
At-risk diagnosis, Condition diagnosed, No diagnosis
Profile
Recruitment Period
2011-2015
Sample size at start or planned sample size if still recruiting
Estimated Current Sample Size
Age at Recruitment
Gender
Male and Female
Abstract
The LRRK2 Cohort Consortium (LCC) comprises three closed studies: the LRRK2 Cross-sectional Study, LRRK2 Longitudinal Study and the 23andMe Blood Collection Study. The LCC followed standardized data acquisition protocols, and clinical data and biological samples are stored in a comprehensive Parkinson’s database and biorepository, respectively. A total of 1,213 Idiopathic PD subjects, 1,168 PD subjects with genetic mutations in LRRK2, 1,123 unaffected subjects with genetic mutations in LRRK2, and 779 Healthy Controls (HC) were recruited.
Country
Canada, China, France, Germany, Israel, Norway, Spain, Tunisia, USA
Contact details
Institution name
The Michael J. Fox Foundation for Parkinson's Research
Website
https://www.michaeljfox.org/page.html?lrrk2-cohort-consortium&navid=lrrk2-cohort-consortium
Principal Investiator (PI)
Contact email
[email protected]
Contact phone number
212-509-0995
Address
Funders (Core support)
The Michael J. Fox Foundation for Parkinsons Research
Variables Collected
Brain related measures: N/A
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Blood pressure
Physical: Cardiovascular, Musculoskeletal, Reproductive, Respiratory
Biological samples: Blood, Cerebral spinal fluid (CSF), Other, Urine
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI), Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG), Single photon emission computerised tomography (SPECT)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances
Health service utilisation: N/A