{"id":7092,"date":"2017-02-20T09:49:40","date_gmt":"2017-02-20T09:49:40","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=7092"},"modified":"2017-02-20T09:57:18","modified_gmt":"2017-02-20T09:57:18","slug":"huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/fi\/2017\/02\/huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows\/","title":{"rendered":"Huntington\u2019s Disease Affects Muscle as Well as Neurons, Study Shows"},"content":{"rendered":"<p>Researchers have discovered that mice with Huntington\u2019s disease (HD) suffer defects in muscle maturation that may explain some symptoms of the disorder. The study, which was published in <em>The Journal of General Physiology<\/em>, suggests that HD is a disease of muscle tissue as well as a neurodegenerative disorder and that therapies targeting skeletal muscle may improve patients\u2019 motor function.<\/p>\n<p>HD is a progressive, and ultimately fatal, disorder caused by a mutation in the huntingtin gene that results in the production of defective huntingtin RNA and protein molecules that disrupt various cellular processes. The cognitive and psychiatric disturbances associated with HD, including memory loss and mood swings, are thought to result from the death of neurons in the striatum and cerebral cortex. But some of the disease\u2019s motor symptoms, such as involuntary movements and muscle rigidity, could arise from the effects of mutant huntingtin in skeletal muscle.<\/p>\n<p>The researchers previously found that mice with an early-onset form of HD showed skeletal muscle defects at late stages of the disease, particularly a decrease in the function of a protein called ClC-1, which conducts chloride ions into the cell. This appeared to be caused by defective processing of the messenger RNA encoding ClC-1 and contributed to muscle hyperexcitability, potentially causing some of the motor symptoms associated with HD. But the loss of ClC-1 function could simply be a late response to the death of neurons innervating skeletal muscle; whether the chloride channel is affected during the onset and progression of HD remained unclear.<\/p>\n<p>In the new study, the researchers examined their HD model mice throughout the course of the disease. They found that the RNA encoding ClC-1 was misprocessed in both HD and control mice when they were young, but, as they grew older, only healthy animals were able to start correctly processing the RNA to produce functional ClC-1. Thus, even before their motor symptoms began to appear, ClC-1 function was reduced in the skeletal muscle of HD mice compared with healthy control animals.<\/p>\n<p>This suggested that muscle maturation might be disrupted in HD mice. The reseachers found that HD mice expressed a form of the muscle motor protein myosin that is usually only produced in newborn mouse muscle. Moreover, they identified similar defects in muscle maturation in a different strain of mice with adult-onset HD.<\/p>\n<p>The researchers say that their results could provide a new opportunity to improve patient care by targeting skeletal muscle tissue. In addition, researchers and clinicians may be able to use the skeletal muscle defects as biomarkers to track the progress of HD, a much easier task than examining patients\u2019 brain tissue.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have discovered that mice with Huntington\u2019s disease (HD) suffer [&hellip;]<\/p>\n<a href=\"https:\/\/neurodegenerationresearch.eu\/fi\/2017\/02\/huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows\/\">View Post<\/a>","protected":false},"author":3,"featured_media":4999,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-7092","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Huntington\u2019s Disease Affects Muscle as Well as Neurons, Study Shows - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/2017\/02\/huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows\/\" \/>\n<meta property=\"og:locale\" content=\"fi_FI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Huntington\u2019s Disease Affects Muscle as Well as Neurons, Study Shows - JPND Neurodegenerative Disease Research\" \/>\n<meta property=\"og:description\" content=\"Researchers have discovered that mice with Huntington\u2019s disease (HD) suffer [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/neurodegenerationresearch.eu\/2017\/02\/huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows\/\" \/>\n<meta property=\"og:site_name\" content=\"JPND Neurodegenerative Disease Research\" \/>\n<meta property=\"article:published_time\" content=\"2017-02-20T09:49:40+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2017-02-20T09:57:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/neurodegenerationresearch.eu\/wp-content\/uploads\/2015\/05\/Huntingtons.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1754\" \/>\n\t<meta property=\"og:image:height\" content=\"1240\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"jpnd\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@JPNDeurope\" \/>\n<meta name=\"twitter:site\" content=\"@JPNDeurope\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"jpnd\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/02\\\/huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/02\\\/huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows\\\/\"},\"author\":{\"name\":\"jpnd\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#\\\/schema\\\/person\\\/a97e49cae588ead81db59e48a4e63c2a\"},\"headline\":\"Huntington\u2019s Disease Affects Muscle as Well as Neurons, Study Shows\",\"datePublished\":\"2017-02-20T09:49:40+00:00\",\"dateModified\":\"2017-02-20T09:57:18+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/02\\\/huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows\\\/\"},\"wordCount\":448,\"publisher\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/02\\\/huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/wp-content\\\/uploads\\\/2015\\\/05\\\/Huntingtons.jpg\",\"articleSection\":[\"Research News (General)\"],\"inLanguage\":\"fi-FI\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/02\\\/huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows\\\/\",\"url\":\"https:\\\/\\\/neurodegenerationresearch.eu\\\/2017\\\/02\\\/huntingtons-disease-affects-muscle-as-well-as-neurons-study-shows\\\/\",\"name\":\"Huntington\u2019s Disease Affects Muscle as Well as Neurons, Study Shows - 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