{"id":3626,"date":"2014-10-03T09:48:18","date_gmt":"2014-10-03T09:48:18","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=3626"},"modified":"2014-10-09T13:37:31","modified_gmt":"2014-10-09T13:37:31","slug":"applying-proteomics-to-parkinsons","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/fr\/2014\/10\/applying-proteomics-to-parkinsons\/","title":{"rendered":"Applying proteomics to Parkinson&rsquo;s"},"content":{"rendered":"<p><em><strong>Scientists studying two genes that are mutated in an early-onset form of Parkinson&rsquo;s disease have deciphered how normal versions of these genes collaborate to help rid cells of damaged mitochondria. <\/strong><\/em><\/p>\n<p>Mitochondria are the cell&rsquo;s primary energy source, and maintaining their health is critical for cellular function. Mitochondrial dysfunction may underlie multiple neurodegenerative diseases, including Parkinson&rsquo;s.<\/p>\n<p>In their analysis <a href=\"http:\/\/www.cell.com\/molecular-cell\/abstract\/S1097-2765(14)00714-X\">published in Molecular Cell<\/a>, Harvard Medical School researchers used powerful quantitative mass spectrometry and live-cell imaging approaches to elucidate a multistep mechanism by which the two proteins mutated in Parkinson&rsquo;s disease\u2014PINK1 and PARKIN\u2014mark mitochondria as damaged by attaching chains of a small protein called ubiquitin. This work paves the way for a deeper understanding of what molecular steps are defective when these proteins are mutated in patients with Parkinson&rsquo;s disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists studying two genes that are mutated in an early-onset [&hellip;]<\/p>\n<a href=\"https:\/\/neurodegenerationresearch.eu\/fr\/2014\/10\/applying-proteomics-to-parkinsons\/\">View Post<\/a>","protected":false},"author":3,"featured_media":3375,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[116,115],"class_list":["post-3626","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news","tag-molecular-pathway","tag-parkinsons-disease-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Applying proteomics to Parkinson&#039;s - 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