{"id":6278,"date":"2016-09-12T14:25:32","date_gmt":"2016-09-12T14:25:32","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=6278"},"modified":"2016-09-12T14:25:32","modified_gmt":"2016-09-12T14:25:32","slug":"a-single-gene-may-protect-against-causes-of-neurodegenerative-diseases-study-says","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/fr\/2016\/09\/a-single-gene-may-protect-against-causes-of-neurodegenerative-diseases-study-says\/","title":{"rendered":"A Single Gene May Protect Against Causes of Neurodegenerative Diseases, Study Says"},"content":{"rendered":"<p>New research has identified how cells protect themselves against \u2018protein clumps\u2019 known to be the cause of neurodegenerative diseases including Alzheimer\u2019s, Parkinson\u2019s and Huntington\u2019s disease.<\/p>\n<p>The study was done using a custom-built laboratory device that can compress neurons inside 3-D cell cultures while using a powerful microscope to continuously monitor changes in cell structure.<\/p>\n<p>The study, published in <em>Cell<\/em>, offers an insight into the role of a gene called UBQLN2 and how it helps to remove toxic protein clumps from the body and protect it from disease.<\/p>\n<p>Using biochemistry, cell biology and sophisticated mouse models, the researchers discovered that the main function of UBQLN2 is to help the cell to remove dangerous protein clumps \u2013 a role which it performs by first detangling clumps, then shredding them to prevent future tangles.<\/p>\n<p>Protein clumps occur as part of the natural aging process, but are normally detangled and disposed of as a result of the gene UBQLN2. However when this gene mutates, or becomes faulty, it can no longer help the cell to remove these toxic protein clumps, which leads to neurodegenerative disease.<\/p>\n<p>Previous work has shown that when the UBQLN2 gene is faulty, it leads to a neurodegenerative disease called Amyotrophic Lateral Sclerosis with Frontotemporal Dementia (ALS\/FTD or motor-neuron disease with dementia). However until this study it was not fully understood why mutation of this gene caused disease.<\/p>\n<p>Now that scientists understand exactly how UBQLN2 works and what it does, they are also able to understand why its mutation appears to be so detrimental to the body.<\/p>\n<p>Indeed they hope that their findings will pave the way for new research into novel treatment options for patients with neurodegenerative diseases.<\/p>\n<p>Paper: <a href=\"http:\/\/eprints.gla.ac.uk\/119558\/\">\u00ab\u00a0UBQLN2 connects the proteasome with the HSP70 system to promote autophagy-independent protein aggregate clearance\u00a0\u00bb<\/a><\/p>\n<p><strong>Source: <a href=\"http:\/\/www.gla.ac.uk\/news\/headline_479758_en.html\">University of Glasgow<\/a><\/strong><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New research has identified how cells protect themselves against \u2018protein [&hellip;]<\/p>\n<a href=\"https:\/\/neurodegenerationresearch.eu\/fr\/2016\/09\/a-single-gene-may-protect-against-causes-of-neurodegenerative-diseases-study-says\/\">View Post<\/a>","protected":false},"author":3,"featured_media":2875,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-6278","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A Single Gene May Protect Against Causes of Neurodegenerative Diseases, Study Says - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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