{"id":5095,"date":"2015-05-17T14:20:39","date_gmt":"2015-05-17T14:20:39","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=5095"},"modified":"2015-05-26T16:06:58","modified_gmt":"2015-05-26T16:06:58","slug":"longitudinal-changes-in-free-water-within-the-substantia-nigra-of-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/hu\/2015\/05\/longitudinal-changes-in-free-water-within-the-substantia-nigra-of-parkinsons-disease\/","title":{"rendered":"Longitudinal changes in free-water within the substantia nigra of Parkinson\u2019s disease"},"content":{"rendered":"

Study demonstrates that free-water provides a potential non-invasive progression marker of the substantia nigra region in the brain.<\/strong><\/em><\/p>\n

Parkinson\u2019s disease is a CNS disorder that results from the loss of cells in various parts of the brain, including a region called the substantia nigra. The substantia nigra cells produce dopamine, a chemical messenger responsible for transmitting signals within the brain that allow for coordination of movement.<\/p>\n

With no objective test or biomarker for Parkinson\u2019s, there is a clear need to develop non-invasive markers of substantia nigra progression in Parkinson\u2019s disease. This study\u2019s authors had previously found elevated free-water levels in the substantia nigra for patients with Parkinson\u2019s disease compared with controls in single-site and multi-site cohorts.<\/p>\n

In this study, published in the journal \u201cBrain\u201d, they tested the hypotheses that free-water levels in the substantia nigra of Parkinson\u2019s disease increase following 1 year of progression, and that baseline free-water levels in the substantia nigra predict the change in bradykinesia following 1 year.
\nThe researchers conducted a longitudinal study in controls (n = 19) and patients with Parkinson\u2019s disease (n = 25). Diffusion imaging and clinical data were collected at baseline and after 1 year. Free-water analyses were performed on diffusion imaging data using blinded, hand-drawn regions of interest in the posterior substantia nigra.<\/p>\n

The results found that free water levels increases with progression of Parkinson\u2019s disease, and predicts subsequent changes in bradykinesia and cognitive status over 1 year, thus demonstrating that free-water provides a potential non-invasive progression marker of the substantia nigra.<\/p>\n

Longitudinal changes in free-water within the substantia nigra of Parkinson\u2019s disease<\/em> <\/strong>
\nEdward Ofori ,et al., \u00a0DOI: http:\/\/dx.doi.org\/10.1093\/brain\/awv136<\/p>\n","protected":false},"excerpt":{"rendered":"

Study demonstrates that free-water provides a potential non-invasive progression marker […]<\/p>\nView Post<\/a>","protected":false},"author":3,"featured_media":4978,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[245,101,115],"class_list":["post-5095","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news","tag-biomarker","tag-longitudinal-cohorts","tag-parkinsons-disease-2"],"acf":[],"yoast_head":"\nLongitudinal changes in free-water within the substantia nigra of Parkinson\u2019s disease - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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