{"id":5743,"date":"2016-03-11T14:45:18","date_gmt":"2016-03-11T14:45:18","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=5743"},"modified":"2016-03-11T14:45:18","modified_gmt":"2016-03-11T14:45:18","slug":"only-a-small-portion-of-synapses-may-be-active-during-neurotransmission","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/hu\/2016\/03\/only-a-small-portion-of-synapses-may-be-active-during-neurotransmission\/","title":{"rendered":"Only a Small Portion of Synapses May Be Active During Neurotransmission"},"content":{"rendered":"

Scientists have developed a new optical technique to study how information is transmitted in the brains of mice. Using this method, they found that only a small portion of synapses \u2014 the connections between cells that control brain activity \u2014 may be active at any given time.<\/p>\n

The study was published in the latest issue of Nature Neuroscience<\/em>.<\/p>\n

To obtain a detailed view of synaptic activity, the researchers developed a novel compound called fluorescent false neurotransmitter 200 (FFN200). When added to brain tissue or nerve cells from mice, FFN200 mimics the brain\u2019s natural neurotransmitters and allows researchers to spy on chemical messaging in action.<\/p>\n

Using a fluorescence microscope, the researchers were able to view the release and reuptake of dopamine \u2014 a neurotransmitter involved in motor learning, habit formation, and reward-seeking behavior \u2014 in individual synapses. When all the neurons were electrically stimulated in a sample of brain tissue, the researchers expected all the synapses to release dopamine. Instead, they found that less than 20 percent of dopaminergic synapses were active following a pulse of electricity.<\/p>\n

\u201cThis particular study didn\u2019t explain what\u2019s causing most of the synapses to remain silent,\u201d said David Sulzer, a co-author of the paper. \u201cIf we can work this out, we may learn a lot more about how alterations in dopamine levels are involved in brain disorders such as Parkinson\u2019s disease, addiction, and schizophrenia.\u201d<\/p>\n

Source: Columbia University Medical Center<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Scientists have developed a new optical technique to study how […]<\/p>\nView Post<\/a>","protected":false},"author":3,"featured_media":4994,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[88,106,180,378,77,115,156,377],"class_list":["post-5743","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news","tag-brain","tag-brain-research","tag-neurodegeneration","tag-neurotransmission","tag-parkinsons","tag-parkinsons-disease-2","tag-research","tag-synapses"],"acf":[],"yoast_head":"\nOnly a Small Portion of Synapses May Be Active During Neurotransmission - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/2016\/03\/only-a-small-portion-of-synapses-may-be-active-during-neurotransmission\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Only a Small Portion of Synapses May Be Active During Neurotransmission - 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