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Dementia with Lewy Bodies (DLB) is the second most common cause of neurodegenerative dementia in older people. The aim of LewyPro is to examine and characterise symptoms and brain changes during the prodromal period of LBD. Earlier diagnosis is important because it facilitates care planning, leads to earlier treatment of cognitive symptoms and enables earlier identification of other symptoms, including parkinsonism.
Lewy Pro is recruiting a group of people with mild cognitive impairment (MCI) and prodromal symptoms suggestive of Dementia with Lewy Bodies (DLB) and following them up annually to assess biomarker changes and clinical course. The initial assessment will include a detailed clinical assessment, a blood sample, a lumbar puncture for cerebrospinal fluid, and a DaTSCAN.
Last Update 21/09/2017
Types Neurodegenerative disease-specific cohort
Participant Types Condition diagnosed
Countries United Kingdom
Genders Male and Female
Sample sizes 0 to 4,999
Ages 60 to 100
Brain related measures Behaviour|Cognitive function|Mental health
Funtional rating Individual physiological|Individual psychological
Anthropometric Blood pressure|Height|Weight
Physical Cardiovascular|Hearing and Vision
Biological samples Blood|Cerebral spinal fluid (CSF)>CSF biomarker data available
Genotyping Gene screening
Brain imaging Single photon emission computerised tomography (SPECT)
Brain banking Consent for brain donation
Lifestyle Alcohol|Smoking
Socio-economic Education|Family circumstances|Housing and accommodation|Income and finances|Informal support|Occupation and employment
Health service utilisation
Institute names Newcastle University
Current Sample Sizes 0 to 4,999
age at recruitment >60
last updated
recruitment period 2005
estimated current sample size number value 194
cohort acronym LewyPro
start date 2005
pi Professor Alan Thomas
website https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729131/
contact details Biomedical Research Building,
Newcastle University Campus for Ageing and Vitality,
Newcastle upon Tyne,
NE4 5PL
abstract LewyPro is a ND specific cohort which recruited 264 participants over 60 in 2005 with MCI and prodromal symptoms suggestive of Lewy Bodies Disease.
funders National Institute for Health Research (NIHR)|Newcastle Biomedical Research Unit|National Health Service (NHS)|Foundation Trust, Newcastle University|Alzheimer’s Research UK
contact email PI Email: [email protected]
contact phone number +44 (0) 231912081322
estimated current sample size 0 to 4,999
sample sizes 265