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Title of the cohort
Is ageing changing? Health, healthy life and cognition across generations: Changing ageing across Generations, Epidemiology to policy
Acronym for cohort
Name of Principal Investigator
| Title | Prof |
| First name | Coral |
| Last name | Brayne |
Address of institution where award is held
| Institution | Institute of Public Health, University of Cambridge |
| Street Address | Robinson Way |
| City | Cambridge |
| Postcode | CB2 0SR |
Country
United Kingdom
Website
http://www.cam-can.org/
Contact email
[email protected]
Funding source
1. The cohort includes, or expects to include, incidence of the following conditions
- Alzheimer’s disease and other dementias
- Parkinson’s disease
- Neurodegenerative disease in general
When studies on the above condition(s) are expected to become possible
2a. Stated aim of the cohort
This research focuses on the cognitive abilities that enable us to function in the world, including memory, attention, emotion, language, and action.
2b. Features distinguishing this cohort from other population cohorts
3a. i) Number of publications that involve use of cohort to date
0
3a. ii) Up to three examples of studies to date (PI, Institution, Title of Study)
3b. Publication list/link to where data or publications are accessible (if available)
3c. Information (i.e. research findings) expected to be gained from the population cohort
4a. Study criteria: age range of participants at recruitment
| Age in years from: | 18 |
| To (‘until death’ if applicable): | until death |
4b. Study criteria: inclusion criteria
The Cam-CAN epidemiology cohort will aim to collect information on approximately 3000 adults (aged 18 years and older) living in the Cambridge City area. Respondents will be selected at random from the population registered with Cambridge City GP surgeries.
4c. Study criteria: exclusion criteria
NA
5. Size of the cohort (i.e. number of participants enrolled)
1,000 – 5,000 participants
6a. Measures used to characterise participants
The respondents will be interviewed in their own homes and will answer a range of questions on demographic information, diet, alcohol, smoking, health problems and, for the older participants, questions on how they manage at home with day to day tasks. There is also an extensive cognitive battery measuring memory, language, executive function and various other cognitive domains. Also included within the interview are objective tests such as reaction time, hearing tests and physical measures. All this information provides a rich description of the population from which the Cam-CAN 700 cohort will be selected. The knowledge of the whole population will enable a deeper understanding of the information provided by the 700 in terms not only of the interdisciplinary questions already mentioned, but also by direct linkage back to the general population to enable questions relevant to public health to be investigated.
6b. Additional measures for participants with a clinical disorder
6c. Are there defined primary and secondary endpoints (e.g. defined health parameters)
No
7. Study design
- Prospective cohort
- Longitudinal
8. Cases matched by
- Other health assessment (specify) / N/A
9a. Does the study include a specialised subset of control participants
No
9b. If yes, description of specialised subset of control participants
10a. i) Data collection start date
01-10-2010
10a. ii) Data collection end date
10a iii) Data collection for this study is
- Data collection ongoing
10b. Plans to continue the cohort study beyond the current projected end date
11. Data collected
12. System in place to enable re-contact with patients for future studies
13a. Format and availability of data stored in a database
| Yes/No | % available | |
| Data summarised in database | ||
| Database is web-based | ||
| Database on spreadsheet | Yes | |
| Database is on paper | ||
| Other (specify) | STATA |
Language used:
English
13b. Format and availability of data held as individual records
| Yes/No | % available | |
| Data held as individual records | ||
| Data is web-based | ||
| Data held on computer based records | Yes | |
| Data held on cards | ||
| Other (specify) |
Language used:
14a. Are data available to other groups
Yes
14b. Access policy/mechanisms for access if data are available to other groups
- Apply to PI or co-ordinator at resource
- Access Committee mechanism
15. Data sharing policy specified as a condition of use
Data made publicly available after a specified time point
16a. Are tissues/samples/DNA available to other groups
No
16b. i) Description of available tissues/samples/DNA
16b. ii) Form available tissues/samples/DNA are supplied in
16b. iii) Is the access policy/mechanism for obtaining samples the same as that for obtaining data
17. Is information on biological characteristics available to other groups
- Yes, for all the cohort
Is ageing changing? Health, healthy life and cognition across generations: Changing ageing across Generations, Epidemiology to policy
Population Cohorts
United Kingdom
Alzheimer’s disease & other dementias|Neurodegenerative disease in general|Parkinson’s disease & PD-related disorders
2011