General Information

Mouse: CB57BL/CH3

Expression of the wild type human alpha-synuclein protein under the control of the mouse Prion Protein (PrP) gene promoter

Endogenous mouse alpha synuclein: Yes

Corresponding human genotype: gene multiplication in familial PD; polymorphism in the noncoding region of the alpha-synuclein locus

Transgene insertion:  not specified

References: Giasson 2002

Transgene expression

  • 3 months: expression of transgene is observed in the cortex, cerebellum, midbrain and spinal cord.


  • no loss of TH-positive neurons is observed

Dopamine Homeostasis

  • Not reported


  • 26 months: no inclusions are observed

Motor Behaviours

  • Up to 28 months: not motor phenotype is observed.

Response to L-DOPA treatment

  • Not reported

Non motor Behaviours

  • Not reported


  • Not reported


  • Not reported



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