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Cohort Acronym
AMPLE
Cohort typeRare neurodegenerative condition
Disease
Alzheimer's disease, Lewy body disease
Participant type
Condition diagnosed
Profile
Recruitment Period
2013
Sample size at start or planned sample size if still recruiting
80
Estimated Current Sample Size
Age at Recruitment
>60
Gender
Male and Female
Abstract
The AMPLE study has been set up to investigate differences and outcomes in those with Lewy body dementia with and without concurrent Alzheimer’s disease/pathology. The principle aim of AMPLE is to undertake amyloid PET imaging in Lewy Body Dementia (LBD) and Alzheimer’s disease (AD) of 80 participants over the age of 60 and investigate the distribution of amyloid burden in LBD relative to AD and controls at baseline. A further aim is to determine the relationship between amyloid levels at baseline, clinical features of the disease, other imaging changes and subsequent clinical course in follow up.
Primary analysis would divide LBD patients into high and low amyloid burden with participants then compared on clinical features with AD-like symptoms and cognitive profiles. Follow up will be completed annually through surveys and clinical examinations.
Last update – 01/02/2017
Country
United Kingdom
Contact details
Institution name
Newcastle University
Principal Investiator (PI)
Professor John O'Brien
Contact phone number
+44 (0) 191 208 1322
Address
Clinical Ageing Research Unit, Campus for Ageing and Vitality, Newcastle upon Tyne, NE4 5PL
Funders (Core support)
NIHR Newcastle Biomedical Research Unit|Avid
Variables Collected
Brain related measures: Behaviour, Cognitive function, Mental health
Funtional rating: Individual physiological, Individual psychological
Anthropometric: N/A
Physical: Cardiovascular, Hearing and Vision
Biological samples: Blood, Cerebral spinal fluid (CSF)
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI), Positron emission tomography (PET) fluorine18 flurodeoxyglucose (FDG)
Brain banking: N/A
Lifestyle: Alcohol, Smoking
Socio-economic: Education
Health service utilisation: N/A
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