Neuroimaging of Inflammation in Memory and Other Disorders

The NIMROD (Neuroimaging of Inflammation in Memory and Other Disorders) study aims to understand the role of inflammation in several forms of dementia, memory loss and depression (Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), progressive supranuclear palsy (PSP), frontotemporal dementia (FTD), late life depression (LLD), mild cognitive impairment (MCI)). It also aims to understand the changes in the immune system, from immune cells and other components in the blood and cerebrospinal fluid.

To achieve this, NIMROD looks at brain changes in dementia, depression and related disorders in several different ways, detecting differences in brain structure and function, measuring inflammation and annual psychology and memory assessments. A further aim is to investigate if neuroinflammation can predict subsequent clinical course, including cognitive and functional decline.

Last update – 01/02/2017

Types Neurodegenerative disease-specific cohort
Participant Types Condition diagnosed
Countries United Kingdom
Genders Male and Female
Sample sizes 0 to 4,999
Ages 40 to 59|60 to 100
Brain related measures Cognitive function|Mental health|Neurological
Funtional rating Caregiver|Individual physiological|Individual psychological
Anthropometric
Physical Cardiovascular
Biological samples Blood|Cerebral spinal fluid (CSF)>CSF biomarker data available
Genotyping
Brain imaging Magnetic resonance imaging (MRI)|Positron emission tomography (PET) – amyloid
Brain banking Consent for brain donation
Lifestyle Alcohol|Physical activity|Smoking
Socio-economic Education|Housing and accommodation|Occupation and employment
Health service utilisation
Institute names University of Cambridge
Current Sample Sizes 0 to 4,999

age at recruitment >50
last updated
recruitment period 2013-17
estimated current sample size number value 145
cohort acronym NIMROD
start date 2013-17
pi Professor John O’Brien
website http://www.neurology.cam.ac.uk/neurology-unit-research-groups/syren/nimrod-2/
contact details Robert Arnold,
Department of Psychiatry,
University of Cambridge,
Herchel Smith Building,
Robinson Way,
Cambridge,
CB2 0SZ
abstract  NIMROD plans to recruit 145 participants between 2013 and 2017 over 50 years old. Its aim is to understand the role of inflammation in specific Neurodegenerative Diseases.
funders  NIHR Biomedical Research Unit in Dementia (BRU)
contact email Email: [email protected]
contact phone number +44 (0)1223 768003
estimated current sample size 0 to 4,999
sample sizes 145+