Oxford Parkinson Disease Centre Discovery Cohort

The OPDC Discovery cohort is a prospective, longitudinal study that has recruited patients with early idiopathic Parkinson Disease, healthy controls and participants at risk of PD. The study also includes participants with REM Sleep Behaviour Disorder. Over 1500 subjects have been recruited to the cohort, including 1087 people with Parkinson’s, 300 healthy controls, 111 First degree PD relatives and 151 PSG-diagnosed REM sleep behaviour disorder, thought to be ‘at-risk’ of developing future Parkinson’s. All patients have a clinical assessment repeated every eighteen months so we can better understand the progression of Parkinson’s over time. Over 500 patients have been seen for a second visit which has allowed us to identify some important differences in the way Parkinson’s progresses in different people.

Last update: 29/12/2016

Types Neurodegenerative disease-specific cohort
Participant Types Condition diagnosed
Countries United Kingdom
Genders Male and Female
Sample sizes 0 to 4,999
Ages 10 to 19|20 to 39
Brain related measures Behaviour|Cognitive function|Mental health|Neurological
Funtional rating Caregiver|Individual physiological|Individual psychological
Anthropometric Blood pressure|Height|Weight
Physical Cardiovascular|Respiratory
Biological samples Blood|Cerebral spinal fluid (CSF)>CSF biomarker data available
Genotyping Gene screening
Brain imaging Magnetic resonance imaging (MRI)
Brain banking Consent for brain donation
Lifestyle Alcohol|Dietary habits|Physical activity|Smoking
Socio-economic Education|Ethnic group|Family circumstances|Housing and accommodation|Income and finances|Marital status|Occupation and employment|Unpaid care
Health service utilisation
Institute names University of Oxford
Current Sample Sizes 0 to 4,999

age at recruitment >18
last updated
recruitment period 2010-15
estimated current sample size number value 1311
cohort acronym OPDC Discovery
start date 2010-15
pi Dr Michele Hu
website http://opdc.medsci.ox.ac.uk/home
contact details Oxford Parkinson’s Disease Centre,
Department of Physiology,
Anatomy and Genetics,
Le Gros Clark Building,
South Parks Road,
Oxford,
OX1 3QX
abstract  The OPDC Discovery cohort is a prospective, longitudinal study that has recruited 1,500 patients between 2010-2015 with either early idiopathic Parkinson Disease, as healthy controls or as participants at risk of PD. The aim is to better understand Parkinson’s over time.
funders  Parkinson’s UK
The Monument Trust
contact email [email protected]
contact phone number +44 (0) 1865 282358
estimated current sample size 0 to 4,999
sample sizes 1500