Parkinson’s Repository of Biomarkers and Networked Datasets

Tracking Parkinson’s, or the PRoBaND study, is a UK-based study of Parkinson’s disease funded entirely by Parkinson’s UK.

There is a wide variation of symptoms and features of Parkinson’s driven by both genetic and external factors.  Our study aims to define and explain these variations by analysing the clinical expression of Parkinson’s in relation to genotypic variation. Tracking Parkinson’s is a multi-centre prospective longitudinal study, informed by epidemiological and biomarker data.

Participants were recruited into three categories:

• Recent onset patients (diagnosed within the last three years) are followed up at 6-month intervals for four years, then every 18-months for a further three years.
• Early onset (patients diagnosed before the age of 50) were followed up at one year.
• Relatives (siblings) of the participants are followed up after three years.

Since 2012, we have been running at 70 sites across the UK.  Recruitment closed in November 2017 and our cohort consists of 2,270 people with Parkinson’s and 344 of their siblings.

NHS Greater Glasgow & Clyde is the study Sponsor and the coordinating study centre is based at the Institute of Neuroscience & Psychology at the University of Glasgow in Scotland.

Types Neurodegenerative disease-specific cohort
Participant Types At-risk diagnosis|Condition diagnosed|No diagnosis
Countries United Kingdom
Genders Male and Female
Sample sizes 0 to 4,999
Ages
Brain related measures
Funtional rating Caregiver|Individual physiological
Anthropometric Blood pressure|Height|Weight
Physical
Biological samples Blood
Genotyping Gene screening
Brain imaging
Brain banking
Lifestyle Dietary habits|Physical activity
Socio-economic Ethnic group|Family circumstances|Martial status
Health service utilisation Formal health and social care service utilisation including private care
Institute names University of Glasgow
Current Sample Sizes 0 to 4,999

age at recruitment 
last updated 20180514
recruitment period 2012-2017
estimated current sample size number value 2,614
cohort acronym PRoBaND
start date 2012-2017
pi Donald Grosset
website www.trackingparkinsons.org.uk
contact details Tracking Parkinson’s
Institute of Neuroscience & Psychology
University of Glasgow
58 Hillhead Street, Room 702
Glasgow
G12 8QB
United Kingdom
abstract  There is a wide variation of symptoms and features of Parkinson’s driven by both genetic and external factors.  Our study aims to define and explain these variations by analysing the clinical expression of Parkinson’s in relation to genotypic variation. Recruitment closed in November 2017 and our cohort consists of 2,270 people with Parkinson’s and 344 of their siblings.
funders  Parkinson’s Disease UK
contact email [email protected]
contact phone number Tel: +44 0141 330 2058
estimated current sample size 2,614
sample sizes 2,614