Piecing together the jigsaw of motor neuron degeneration

A recent research study identified a previously unknown cellular process that causes selective motor neuron degeneration

A recent research study identified a previously unknown cellular process that causes selective motor neuron degeneration, but it also appears to tie together several of the pieces of the pathological jigsaw in motor neuron disease:

• disruption of RNA metabolism
• oxidative stress and
• programmed cell death pathways

Published in the journal Nature, from an international consortium, led by the scientists from the Austrian Academy of Sciences in Vienna, the researchers created a mouse that has a defect in an enzyme called CLP1 and these mice develop progressive motor neuron degeneration.

Full article is available at the link below: