PINK1 Triple (DJ1-/-, Parkin-/-Pink1-/-) – Mouse

General Information

Mouse: C57BL/6 x 129/Sv

Mice with triple deletion of the Parkin, PINK1 and DJ-1 genes. Mice are viable and fertile without any obvious abnormalities.

Corresponding human genotype: No equivalent triple gene mutations have been described in patients with Parkinson’s disease. Autosomal recessive mutation in the PINK1 gene leading the early-onset Parkinson’s disease.

Mutated gene: PINK1, Parkin and DJ-1

References: Kitada 2009

Neurodegeneration

  • 3, 16 and 24 months: normal morphology and no loss of TH-positive neurons are observed in the SN. No differences are observed in noradrenergic neurons in the locus coeruleus

Dopamine Homeostasis

  • 16 months: no changes in the levels of dopamine and dopamine metabolites are observed in the striatum.
  • 24 months: a significant increase in dopamine levels is detected.

Inclusions

  • Not reported

Motor Behaviours

  • Not reported

Response to dopaminergic treatment

  • Not reported

Non motor Behaviours

  • Not reported

Electrophysiology

  • Not reported

Neuroinflammation

  • Not reported
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