{"id":7200,"date":"2017-03-10T09:19:29","date_gmt":"2017-03-10T09:19:29","guid":{"rendered":"http:\/\/www.neurodegenerationresearch.eu\/?p=7200"},"modified":"2017-03-10T09:19:29","modified_gmt":"2017-03-10T09:19:29","slug":"genetic-connection-between-parkinsons-and-cognitive-decline","status":"publish","type":"post","link":"https:\/\/neurodegenerationresearch.eu\/pl\/2017\/03\/genetic-connection-between-parkinsons-and-cognitive-decline\/","title":{"rendered":"Genetic Connection Between Parkinson\u2019s and Cognitive Decline"},"content":{"rendered":"

Although the hallmark symptoms of Parkinson\u2019s disease (PD) \u2013 such as involuntary shaking, slowness of movement and muscle rigidity \u2013 are related to movement, recent evidence has suggested that memory impairment plays an outsized role in diminished quality of life and the burden placed on caregivers.<\/p>\n

A new study finds that mutations in the gene for glucocerebrosidase (GBA), known to be a risk factor for PD, also have a powerful influence on the development of cognitive decline. The study was published in Annals of Neurology<\/em>, the journal of the American Neurological Association.<\/p>\n

Two defective copies of the GBA gene are known to cause Gaucher\u2019s disease, a childhood disorder that causes death by age two or severe neurologic complications. One defective copy of the gene was once thought to be of little consequence, but has recently emerged as a common risk factor for Parkinson\u2019s disease.<\/p>\n

The new report examined 2,304 patients from the US, Canada and Europe, finding that 10 percent carried one (or more) defects in copies of the GBA gene. Patients carrying one defective GBA gene copy had an increased risk of memory troubles. This effect was most troublesome for patients carrying a GBA copy with the most severe type of defect \u2014 known as a neuropathic GBA mutation \u2014 whose risk of developing cognitive decline over time was increased by 217 percent. Approximately half of the carriers of a neuropathic GBA mutation developed global cognitive impairment within ten years of being diagnosed with Parkinson\u2019s. Among the PD patients without a mutation, only about 20 percent developed this decline in cognitive function.<\/p>\n

Therapies for Gaucher disease have been available since 1994. The researchers hope that their findings will open the door for a completely new type of clinical trials in Parkinson\u2019s \u2014 GBA-directed trials designed to proactively prevent memory troubles in patients with movement-related symptoms.<\/p>\n

Paper: \u201cSpecifically neuropathic Gaucher\u2019s mutations accelerate cognitive decline in Parkinson\u2019s\u201d<\/a><\/strong>
\n Reprinted from materials provided by Brigham and Women\u2019s Hospital<\/a>.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Although the hallmark symptoms of Parkinson\u2019s disease (PD) \u2013 such […]<\/p>\nView Post<\/a>","protected":false},"author":3,"featured_media":4978,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[22],"tags":[],"class_list":["post-7200","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-news"],"acf":[],"yoast_head":"\nGenetic Connection Between Parkinson\u2019s and Cognitive Decline - JPND Neurodegenerative Disease Research<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/neurodegenerationresearch.eu\/2017\/03\/genetic-connection-between-parkinsons-and-cognitive-decline\/\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genetic Connection Between Parkinson\u2019s and Cognitive Decline - 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