This website is now the new JPND's archival platform. This website hosts all of JPND's archived content and resources.
Please continue to visit this site to access publications, videos and reports from JPND's activities.
General Information
Mouse: CB57BL/CH3
Expression of the wild type human alpha-synuclein protein under the control of the mouse Prion Protein (PrP) gene promoter
Endogenous mouse alpha synuclein: Yes
Corresponding human genotype: gene multiplication in familial PD; polymorphism in the noncoding region of the alpha-synuclein locus
Transgene insertion: not specified
References: Giasson 2002
Transgene expression
- 3 months: expression of transgene is observed in the cortex, cerebellum, midbrain and spinal cord.
Neurodegeneration
- no loss of TH-positive neurons is observed
Dopamine Homeostasis
- Not reported
Inclusions
- 26 months: no inclusions are observed
Motor Behaviours
- Up to 28 months: not motor phenotype is observed.
Response to L-DOPA treatment
- Not reported
Non motor Behaviours
- Not reported
Electrophysiology
- Not reported
Neuroinflammation
- Not reported